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Zepatier for Kidney Failure (THINKER Trial)
Phase 1 & 2
Waitlist Available
Led By Stacey Prenner, MD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Weigh at least 50kg
No active illicit substance abuse
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 52 weeks
Awards & highlights
THINKER Trial Summary
This trial is testing whether it's safe to transplant kidneys from donors with Hepatitis C into patients without it, who will then be treated for the virus.
Eligible Conditions
- Kidney Failure
THINKER Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTHINKER Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline to 52 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 52 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of Subjects Cured
Number of Subjects With SAE Attributable to HCV Therapy
Side effects data
From 2018 Phase 4 trial • 10 Patients • NCT0278164933%
Pulomonary infection
100%
80%
60%
40%
20%
0%
Study treatment Arm
Donor Genotype 2 or 3
Donor Genotype 1a no Resistance or 1b
Donor Genotype 1a With Resistance
THINKER Trial Design
1Treatment groups
Experimental Treatment
Group I: Direct-acting antiviral treatment for HCVExperimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mavyret
2018
Completed Phase 4
~110
Zepatier
2016
Completed Phase 4
~110
Find a Location
Who is running the clinical trial?
University of PennsylvaniaLead Sponsor
1,992 Previous Clinical Trials
42,875,298 Total Patients Enrolled
2 Trials studying Kidney Failure
94,017 Patients Enrolled for Kidney Failure
Merck Sharp & Dohme LLCIndustry Sponsor
3,862 Previous Clinical Trials
5,049,638 Total Patients Enrolled
1 Trials studying Kidney Failure
8 Patients Enrolled for Kidney Failure
Stacey Prenner, MDPrincipal InvestigatorUniversity of Hospital of Pennsylvania
Frequently Asked Questions
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