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Opioid Analgesic

morphine for Subarachnoid Hemorrhage

Phase 1 & 2
Waitlist Available
Led By Richard I Hall, MD
Research Sponsored by Dalhousie University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up prospective
Awards & highlights

Study Summary

Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood brain barrier. This loss results in the penetration into the brain of certain drugs that are normally excluded by the transporter protein. In this study the working hypothesis is that the agitation observed in patients with CNS trauma treated with morphine is related to the inflammation evoked loss of PGP in the blood brain barrier and the accumulation of the morphine metabolite 3-morphine glucuronide.

Eligible Conditions
  • Subarachnoid Hemorrhage
  • Head Trauma
  • Head Injuries

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~prospective
This trial's timeline: 3 weeks for screening, Varies for treatment, and prospective for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
see the ratios of cerebrospinal fluid (CSF)/blood increase with time as the inflammation progresses
Secondary outcome measures
ratios of morphine and its metabolites in CSF and blood with the RASS will determine if observed CNS stimulation occurs at a time when the levels of 3-morphine glucuronide is high on the brain side of the blood brain barrier

Trial Design

1Treatment groups
Active Control
Group I: 0Active Control1 Intervention

Find a Location

Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,345 Previous Clinical Trials
26,453,494 Total Patients Enrolled
1 Trials studying Subarachnoid Hemorrhage
740 Patients Enrolled for Subarachnoid Hemorrhage
Dalhousie UniversityLead Sponsor
167 Previous Clinical Trials
403,118 Total Patients Enrolled
Richard I Hall, MDPrincipal InvestigatorCapital Health- QE II HSC
1 Previous Clinical Trials
35 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Problems With Morphine Use in Patients With a Severe Brain Injury
2005. "Problems With Morphine Use in Patients With a Severe Brain Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00196131.
All > Brain Injury
~1 spots leftby May 2025
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