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Anti-caries agent

Silver diamine fluoride for Tooth Decay

Phase 2

Waitlist Available

Led By Travis Nelson, DDS

Research Sponsored by Advantage Silver Dental Arrest, LLC

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 21 days

Awards & highlights

Study Summary

This trial studies how well a cavity-fighting medicine works in children, and looks at its effects in the body over time.

Who is the study for?

This trial is for healthy children aged 13 months to 13 years who live close to the study site and have at least one untreated cavity. Kids with mouth sores, allergies to silver or fluoride, or recent SDF treatments can't join.Check my eligibility

What is being tested?

The study tests how a tooth decay treatment called Advantage Arrest (38% silver diamine fluoride) behaves in kids' bodies. After treating cavities, researchers will check blood levels of the drug at different times.See study design

What are the potential side effects?

Possible side effects may include temporary staining of teeth or skin where applied, mild irritation around the treated area, and very rarely an allergic reaction due to sensitivity to silver or fluoride.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 21 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~21 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 21 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Area Under Curve, Fluoride

Area Under Curve, Silver

Fluoride Cmax

+3 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Silver diamine fluorideExperimental Treatment1 Intervention

Silver diamine fluoride, 38%, topical, single application

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

38% silver diamine fluoride

2017

Completed Phase 2

~20

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of WashingtonOTHER

1,738 Previous Clinical Trials

1,844,328 Total Patients Enrolled

Advantage Silver Dental Arrest, LLCLead Sponsor

5 Previous Clinical Trials

600 Total Patients Enrolled

Travis Nelson, DDSPrincipal InvestigatorUniversity of Washington

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment recruiting elderly individuals in its participant pool?

"Only patients aged 13 Months to 13 can be included in this trial. Those under 18 years old have 56 trials available and those over 65 are eligible for 31 studies."

Answered by AI

Who is eligible to participate in this research?

"This investigation is seeking 30 children aged 13 months-13 years with untreated dental caries lesions in the dentin. Additionally, participants must reside within 10 miles of the research centre."

Answered by AI

Has the FDA given clearance for Silver diamine fluoride as a treatment?

"We have assigned silver diamine fluoride a safety rating of 2, in light of the fact that there is preliminary evidence indicating its security but no data yet proving its efficacy."

Answered by AI

Is this research protocol currently recruiting participants?

"According to clinicaltrials.gov, this trial appears to have been concluded as the post-date and last update date are both from January of 2023. Despite that, there are still 100 other medical studies seeking volunteers at present time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

2023. "Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05670743.