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Fluoride

Silver Diamine Fluoride for Tooth Decay

N/A
Waitlist Available
Led By Amal Noureldin, DDS
Research Sponsored by Texas A & M University Baylor College Of Dentistry
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test whether silver diamine fluoride can prevent tooth decay in cancer patients being treated with radiation.

Who is the study for?
This trial is for individuals with head and neck cancer who are undergoing radiation therapy that includes the jaws. It's not suitable for those expected to live less than a year or whose radiation treatment doesn't involve the jaw area.Check my eligibility
What is being tested?
The study tests if applying a high-strength fluoride solution (38% silver diamine fluoride) can prevent tooth decay better than a standard fluoride gel in oral cancer patients receiving radiation.See study design
What are the potential side effects?
Possible side effects may include temporary staining of teeth, mild irritation to gums or mouth tissues, and an unusual metallic taste during application.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dental Caries (DMFS)
Secondary outcome measures
Bleeding Index
Gingival Index
MD Anderson Symptom Inventory-Head and Neck
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PackageExperimental Treatment2 Interventions
Topical application of 38% silver diamine fluoride plus 5000 PPM fluoride gel 1 mo before and 1 and 3 months after radiation treatment
Group II: Gel AloneActive Control1 Intervention
Placebo application of silver diamine fluoride plus 5000 PPM fluoride gel 1 mo before and 1 and 3 months after radiation treatment

Find a Location

Who is running the clinical trial?

University of WashingtonOTHER
1,738 Previous Clinical Trials
1,844,291 Total Patients Enrolled
Texas A & M University Baylor College Of DentistryLead Sponsor
4 Previous Clinical Trials
154 Total Patients Enrolled
Amal Noureldin, DDSPrincipal InvestigatorTAMU Baylor College of Dentistry

Media Library

Silver Diamine Fluoride (Fluoride) Clinical Trial Eligibility Overview. Trial Name: NCT05403125 — N/A
Tooth Decay Research Study Groups: Package, Gel Alone
Tooth Decay Clinical Trial 2023: Silver Diamine Fluoride Highlights & Side Effects. Trial Name: NCT05403125 — N/A
Silver Diamine Fluoride (Fluoride) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05403125 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the recruitment phase of this clinical trial still open?

"Clinicaltrials.gov reveals that this study, which was made available on June 1st 2022, is no longer recruiting patients. Although the trial has concluded its recruitment period, there are currently 103 other clinical trials actively looking for volunteers."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
Baylor College of Dentistry
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
SDF Application in Oral Cancer Patients to Prevent Dental Caries
Amal Noureldin 2022. "SDF Application in Oral Cancer Patients to Prevent Dental Caries". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05403125.
~21 spots leftby Apr 2025
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