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Fluoride Toothpaste

Fluoride Toothpaste + Mouthrinse for Preventing Tooth Decay

Q: Does this research endeavor currently have any open slots for participants?

<p>Based on the information hosted by clinicaltrials.gov, this research is not actively seeking participants as of now; first posted in March 23rd 2023 and last edited on April 4th 2023. Nonetheless, there are 94 other studies that have open recruitment at present.</p>

Phase < 1

Waitlist Available

Research Sponsored by University of Michigan

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0 to 60 minutes after the interventions

Awards & highlights

Study Summary

This trial will study the effects of fluoride toothpaste and mouthrinse on saliva in 20 adults from Ann Arbor, MI.

Who is the study for?

This trial is for adults over 18 with good oral and general health, normal saliva flow, no urgent dental needs, living in Ann Arbor, MI. They must understand the study protocol and commit to its full duration. It's not for those with poor health or low saliva production.Check my eligibility

What is being tested?

The study tests fluoride availability in saliva after using two types of toothpaste (regular Crest Cavity Protection and prescription-strength Colgate PreviDent 5000+) alone or followed by Act Mint Fluoride Rinse. Participants will try all four combinations in a crossover design.See study design

What are the potential side effects?

While specific side effects are not listed for this trial, typical reactions to fluoride products may include mild irritation inside the mouth or an upset stomach if swallowed.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0 to 60 minutes after the interventions

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0 to 60 minutes after the interventions

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 to 60 minutes after the interventions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Area under the curve of fluoride bioavailability in saliva

Secondary outcome measures

Maximum fluoride concentration in saliva

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Colgate PreviDent 5000+ followed by Act Mint Fluoride RinseExperimental Treatment1 Intervention

Colgate PreviDent 5000+ (5,000 ppm F) will be used to brush teeth, followed by a mouth rinse with Act Mint Fluoride Rinse (226 ppm)

Group II: Colgate PreviDent 5000+Active Control1 Intervention

Colgate PreviDent 5000+ (5,000 ppm F) will be used to brush teeth, followed by a mouth rinse with tap water

Group III: Crest Cavity ProtectionActive Control1 Intervention

Crest Cavity Protection toothpaste (1,100 ppm F) will be used to brush teeth, followed by a mouth rinse with tap water

Group IV: Crest Cavity Protection followed by Act Mint Fluoride RinseActive Control1 Intervention

Crest Cavity Protection toothpaste (1,100 ppm F) will be used to brush teeth, followed by a mouth rinse with Act Mint Fluoride Rinse (226 ppm)

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor

1,795 Previous Clinical Trials

6,373,916 Total Patients Enrolled

Media Library

Over-the-counter fluoride toothpaste (Fluoride Toothpaste) Clinical Trial Eligibility Overview. Trial Name: NCT05601154 — Phase < 1

Tooth Decay Research Study Groups: Colgate PreviDent 5000+, Colgate PreviDent 5000+ followed by Act Mint Fluoride Rinse, Crest Cavity Protection, Crest Cavity Protection followed by Act Mint Fluoride Rinse

Tooth Decay Clinical Trial 2023: Over-the-counter fluoride toothpaste Highlights & Side Effects. Trial Name: NCT05601154 — Phase < 1

Over-the-counter fluoride toothpaste (Fluoride Toothpaste) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05601154 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor currently have any open slots for participants?

"Based on the information hosted by clinicaltrials.gov, this research is not actively seeking participants as of now; first posted in March 23rd 2023 and last edited on April 4th 2023. Nonetheless, there are 94 other studies that have open recruitment at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses

Livia Tenuta 2023. "Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05601154.