Glecaprevir / Pibrentasvir Pill for Moral Injury

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
White River Junction VAMC, White River Junction, VT
Moral Injury+1 More
Glecaprevir / Pibrentasvir Pill - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

An open-label pilot study to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV).

Eligible Conditions

  • Moral Injury
  • Ptsd

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: Post treatment: 7 days after medication completion

Day 7
Clinical Administered PTSD Scale version 5 (CAPS-5)
World Health Organization Disability Assessment Schedule, version 2.0 (WHODAS)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Active Drug
1 of 1
Experimental Treatment

10 Total Participants · 1 Treatment Group

Primary Treatment: Glecaprevir / Pibrentasvir Pill · No Placebo Group · Phase 2 & 3

Active Drug
Drug
Experimental Group · 1 Intervention: Glecaprevir / Pibrentasvir Pill · Intervention Types: Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: post treatment: 7 days after medication completion
Closest Location: White River Junction VAMC · White River Junction, VT
Photo of vermont 1Photo of vermont 2Photo of vermont 3
2013First Recorded Clinical Trial
0 TrialsResearching Moral Injury
7 CompletedClinical Trials

Who is running the clinical trial?

White River Junction Veterans Affairs Medical CenterLead Sponsor
25 Previous Clinical Trials
16,514 Total Patients Enrolled
Bradley V Watts, MD, MPHPrincipal InvestigatorWhite River Junction Veterans Affairs Medical Center
1 Previous Clinical Trials
132 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have experienced a traumatic event that causes you to have symptoms of PTSD.
You are eligible for VA healthcare.\n
If female with childbearing potential, use of acceptable method of birth control (i.e.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.