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Low-Dose Clonidine for PTSD
Study Summary
This trial is testing whether the drug clonidine can help improve symptoms of PTSD in veterans. It will look at daytime, nighttime, and sleep-related behaviors.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You are a former member of the US military.I am taking Catapres or Kapvay (clonidine).I am taking Aldomet (Methyldopa).You have experienced traumatic events and have symptoms such as flashbacks or nightmares (PCL5 items 1-5) or avoidance of thoughts or feelings related to the event (PCL5 items 15-20) with a score of 10 or higher.You have used or are currently using cannabis.I have been prescribed clonidine in the last 6 months.I am taking Seroquel (quetiapine).You have a score of 3 or more on the CAPS nightmare items B2 and E6.My kidney disease is in stage 5.I am not taking any barbiturate medications.You are not allowed to use inhalants during the study.I am taking an α2 agonist medication.I have a legal guardian.I am not taking Moban (molindone).I am currently taking Navane (thiothixene).I am taking Prolixin for my condition.I am taking Thorazine.I am currently taking Abilify.I am taking Clozaril (clozapine).I am currently taking benzodiazepines.I am taking Cyproheptadine.You have high scores on questions related to intrusive thoughts or disturbing memories.I have a current diagnosis.I can safely take clonidine without any known contraindications.You have an addiction to opioid drugs.You can speak and understand English.You have a history of a specific heart condition called 2nd or 3rd degree atrioventricular block.I am not taking Serentil (mesoridazine).I have a history of Raynaud's phenomenon.You are a former member of the US military.My blood pressure is above 160/100 or I am experiencing a hypertensive emergency.You are allergic to clonidine.I have a history of slow heartbeats.I have a history of pheochromocytoma.I am taking Tamsulosin.You have a screening score of 30 or higher on the CAPS.I am taking medication for high blood pressure or prostate issues.I am currently taking Alfuzosin.You are currently using heroin.You have answered questions 15-20 with a score of 2 or higher, twice.You are able to speak and understand English.I am taking Haldol (haloperidol).I am taking Loxitane (loxapine).I am currently taking or have taken opiates like buprenorphine, hydrocodone, or oxycodone.I am taking Lucemyra (Lofexidine).I am not taking Mellaril for my condition.I am currently taking Geodon (ziprasidone).I am taking Risperdal (risperidone).I am considered unable to understand or participate in the study due to cognitive reasons.I am 18 years old or older.I am currently undergoing exposure therapy.I haven't started any new mental health therapies in the last month.My blood pressure is below 100/60 or I experience symptoms like dizziness.I have not had a heart attack in the last 6 months.I am taking pain medication other than opiates.I have sleep apnea and do not follow my treatment plan.You have a problem with using marijuana.I am taking Silodosin.I have been diagnosed with PTSD by a healthcare professional.I am currently taking Prazosin.I am taking Trilafon (perphenazine).I am 18 years old or older.I have been diagnosed with PTSD by a healthcare professional.I am currently taking Terazosin.I am currently taking Doxazosin.I have not used any unprescribed drugs or misused prescribed ones in the last 30 days.I am currently taking Zanaflex (Tizanidine).I am taking Zyprexa (olanzapine).You have a problem with drinking too much alcohol.I am taking Intuniv (Guanfacine).I am taking Stelazine for my condition.I have had a stroke or cerebrovascular disease in the last 6 months.I am taking antipsychotic medication.I am not taking sedatives, sleeping pills, or tranquilizers.
- Group 1: Clonidine Phase
- Group 2: Placebo Phase
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the researchers hoping to achieve with this clinical trial?
"This study will assess the primary outcome of change in PTSD symptoms as measured by the PCL-5 scale at 6 weeks. Secondary outcomes include qualitative data on participants' verbal feedback and changes in heart rate and clinical global impressions from baseline at 6 weeks."
Are there any other investigations that have included Clonidine Pill in their research?
"As of now, there are 23 clinical trials ongoing for Clonidine Pill. Of these, 7 have reached Phase 3. Although a number of the studies are based in Boston, Massachusetts, 75 different locations across the globe are running tests for this pill."
What are the harmful effects of Clonidine Pill?
"Clonidine Pill has been studied in multiple Phase 3 trials, which provides some efficacy data and supports the safety of the medication."
Are new participants being enrolled in this experiment at present?
"According to the most recent information available on clinicaltrials.gov, this trial is not recruiting patients at this time. The study was posted on February 1st 2023 and last updated on November 1st 2022. 595 other studies are currently enrolling patients."
How many test subjects are involved in this clinical trial?
"Currently, this trial is not looking for patients. The study was first posted on February 1st 2023 and the most recent edit was on November 1st 2022. If you are interested in other studies, 572 trials for post-traumatic stress disorder (ptsd) and 23 trials for Clonidine Pill are presently enrolling participants."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
How responsive is this trial?
Average response time
- < 2 Days
Typically responds via
Most responsive sites:
- Aurora Psychiatric Hospital: < 48 hours
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