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Web-based Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder (Web CBT Trial)

Phase 1 & 2
Waitlist Available
Led By Stephen Maisto, Ph.D.
Research Sponsored by National Development and Research Institutes, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 month post-intervention
Awards & highlights

Web CBT Trial Summary

The proposed study involves developing and evaluating an interactive, web-based CBT intervention for OEF/OIF Veterans with hazardous or problematic substance use and PTSD symptoms (PTSD or subsyndromal PTSD). The intervention will address the special culture and experiences of the investigators targeted population (OEF/OIF Veterans). The web-based CBT intervention includes 24 modules, to be used across 24 sessions targeting OEF/OIF Veterans with hazardous or problematic substance use and PTSD symptoms. The investigators ask participants to complete 2 sessions per week (one module per session) for 12 weeks. The first 18 modules to be completed across 18 sessions (9 weeks) are considered core modules relevant to all Veterans in the target population. These modules are designed to reduce posttraumatic stress symptoms as well as reduce and prevent the escalation of problematic substance use. The remaining 6 module topics are considered "optional" and are used based on the interest and clinical need of various sub-groups of VA patients. The study includes initial input as well as feedback on a beta version from experts who have worked with OEF/OIF veterans with PTSD and substance abuse problems as well as input/feedback from the target population (the Veterans themselves). In addition to presenting content grounded in evidence-based CBT interventions, the program also employs state of the art technologies to deliver module content grounded in evidence-based learning principles, including Computer-Assisted Instruction, Computer Simulation and other interactive exercises.

Eligible Conditions
  • Post-Traumatic Stress Disorder
  • Substance Use Disorder

Web CBT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 month post-intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 month post-intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Alcohol and Drug Use
Cost-Effectiveness
PTSD Symptomatology
+1 more
Secondary outcome measures
Insomnia
Pain Severity and Pain Interference
Psychological Distress
+2 more

Web CBT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Web-based Cognitive Behavioral TreatmentExperimental Treatment1 Intervention
Participants who are randomly assigned to the treatment condition will receive the same standard care as those in the control condition and they will also receive access to the web-based CBT intervention. Participants in this condition will be asked to complete 24 CBT sessions, 2 sessions/topics per week for 12 weeks. Participants will be asked to complete the 18 "core modules" of the program during the first 9 weeks of the trial and then to re-visit important modules and complete optional modules of their choice during the final 3 weeks of the trial.
Group II: Treatment as UsualActive Control1 Intervention
TAU consists of the usual Veterans Integrated Service Network 2 (VISN) primary care services. As we have described, all of the participants will be recruited from patients presenting for treatment typically for physical complaints in primary care clinics in VA's VISN 2 (Upstate NY). VISN 2 officially practices a co-located, collaborative care model of integrated (behavioral health and physical health) in its primary care clinics. This integrated model has been implemented widely in both VA and non-VA primary care clinics in the United States .

Find a Location

Who is running the clinical trial?

National Development and Research Institutes, Inc.Lead Sponsor
37 Previous Clinical Trials
12,730 Total Patients Enrolled
The VA Western New York Healthcare SystemFED
7 Previous Clinical Trials
653 Total Patients Enrolled
Syracuse VA Medical CenterFED
13 Previous Clinical Trials
953 Total Patients Enrolled

Frequently Asked Questions

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~15 spots leftby May 2025