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Cancer Metabolism Inhibitor

RLY-1971 for Solid Tumors

Phase 1
Waitlist Available
Research Sponsored by Hoffmann-La Roche
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (an average of one year)
Awards & highlights

Study Summary

This trial is testing a new drug, RLY-1971, to see if it can treat advanced or metastatic solid tumors.

Eligible Conditions
  • Solid Tumors

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (an average of one year)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (an average of one year) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Tolerated Dose (MTD)
Recommended Phase 2 Dose (RP2D)
Secondary outcome measures
Disease Control Rate (DCR)
Objective Response Rate (ORR)
Plasma concentration levels of RLY-1971
Other outcome measures
Changes in phospho-ERK levels
Duration of Response (DOR)
Progression-free Survival (PFS)
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: RLY-1971 - Dose Escalation/ExpansionExperimental Treatment1 Intervention
Dose Escalation: Oral dose of RLY-1971 until Maximum Tolerated Dose (MTD), and Recommended Phase 2 dose (RP2D) are identified Dose Expansion: Oral dose of RLY-1971 once Maximum Tolerated Dose (MTD), and Recommended Phase 2 Dose (RP2D) are identified.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
RLY-1971
2020
Completed Phase 1
~60

Find a Location

Who is running the clinical trial?

Hoffmann-La RocheLead Sponsor
2,432 Previous Clinical Trials
1,090,167 Total Patients Enrolled
Clinical TrialsStudy DirectorHoffmann-La Roche
2,201 Previous Clinical Trials
888,884 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
RLY-1971 in Subjects With Advanced or Metastatic Solid Tumors
2020. "RLY-1971 in Subjects With Advanced or Metastatic Solid Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04252339.
~11 spots leftby Apr 2025
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