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SGLT2 Inhibitor

Dapagliflozin for Heart Failure

Phase 2
Waitlist Available
Led By Barry A Borlaug
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 24 weeks
Awards & highlights

Study Summary

This trial will test whether Dapa can improve heart function in people with HFpEF.

Eligible Conditions
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pulmonary Capillary Wedge Pressure (PCWP) at Maximal Exercise
Pulmonary Capillary Wedge Pressure (PCWP) at Rest
Secondary outcome measures
Change in Body Weight
Change in Mean Pulmonary Arterial Pressure (PA) at Maximal Exercise
Change in Mean Pulmonary Arterial Pressure (PA) at Rest
+4 more

Side effects data

From 2018 Phase 4 trial • 30 Patients • NCT03006471
20%
Cervicovaginal infection
13%
Urinary tract infections
100%
80%
60%
40%
20%
0%
Study treatment Arm
Dapagliflozin
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Dapagliflozin GroupExperimental Treatment1 Intervention
Subjects with HFpEF will take the study drug dapagliflozin daily
Group II: Placebo GroupPlacebo Group1 Intervention
Subjects with HFpEF will take a placebo daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dapagliflozin
2014
Completed Phase 4
~64880

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,206 Previous Clinical Trials
3,767,045 Total Patients Enrolled
72 Trials studying Heart Failure
1,021,990 Patients Enrolled for Heart Failure
Barry A BorlaugPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
23 Total Patients Enrolled
1 Trials studying Heart Failure
23 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experimental trial a pioneer of its type?

"AstraZeneca spearheaded the inaugural clinical trial for Dapagliflozin in 2014, which included 700 participants. After gaining N/A approval that same year, 63 active studies are now taking place globally across 235 cities and 50 nations."

Answered by AI

Has the U.S. Food and Drug Administration sanctioned Dapagliflozin?

"Given that this is a phase 2 study, with data in support of safety but not efficacy, our team at Power gave Dapagliflozin a score of 2."

Answered by AI

In what ways has Dapagliflozin been utilized in medical treatments?

"When treating pharmaceutical preparations, dapagliflozin is often the medication of choice. It can also be a viable solution for patients who have tried dieting and exercising with minimal success or those not responding to single therapy."

Answered by AI

How many participants have been admitted to this research project?

"Indeed, the information available on clinicaltrials.gov attests to this trial's ongoing recruitment efforts; it was first posted in February 2021 and has most recently been updated in March 2022. At present, 46 participants are needed from a single medical site."

Answered by AI

Are any new participants being sought out for this research endeavor?

"Affirmative. Clinicaltrials.gov provides evidence that the clinical trial is still recruiting, which began on February 24th 2021 and was last modified on March 23rd 2022. A total of 46 patients will be accepted at one site for enrollment into this study."

Answered by AI
~9 spots leftby Apr 2025