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High Ratio CBD:THC vs. High Ratio THC:CBD Cannabis Oil for Stress and Inhibition in Cannabis Users (CAPU RISE Trial)
CAPU RISE Trial Summary
This trial is examining the neurological effects of cannabis on stress reactivity and inhibition in healthy cannabis and stimulant co-users, with the expectation that high ratio CBD:THC cannabis oil will have the largest effect and low ratio CBD:THC cannabis oil will have a moderate effect on outcome measures compared to placebo.
CAPU RISE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCAPU RISE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CAPU RISE Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
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- I have used cannabis weekly for the last month, including twice orally.I am allergic or have had bad reactions to CBD or THC.I am between 19 and 35 years old.You are actively trying to become pregnant.I have a major health issue like liver disease, diabetes, chronic pain, heart problems, or risk of delirium.I have received 2 doses of an approved COVID-19 vaccine.I am taking medications that may affect my brain, heart, or metabolism.I cannot attend all the study sessions as scheduled.You have a condition that affects your thinking or learning abilities, like autism or ADHD. You also have a mental health disorder, like schizophrenia or depression. You may have trouble with your senses, like hearing, that can't be fixed.I have had heavy drinking episodes in the past year.You have had a bad reaction to cannabis in the last 6 months.I have used at least 20mg of CBD before.I have used at least 5mg of THC before.I am not trying to become pregnant or using fertility treatments during the study.I am using a reliable method of birth control and will continue for the study's duration.I am between 19 and 35 years old.You have used methamphetamine.\nI am not pregnant, nursing, or I am using effective birth control.I have not used MDMA/ecstasy/molly.I take at least 50 mg of CBD on average.You have an allergy to cannabinoids or palm/coconut oil.I use at least 10 mg of THC on average.You have used opioid drugs more than two times in the last 30 days.I have been diagnosed with a sleep disorder.I will not donate sperm during the study.You are left-handed or can use both hands equally well (ambidextrous).You have difficulty with numbers and calculations (dyscalculia).
- Group 1: Cannabis oil with a high ratio of THC to CBD
- Group 2: Cannabis oil with a high ratio of CBD to THC
- Group 3: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is there potential for harm when patients consume a Cannabis oil with an elevated CBD to THC ratio?
"Our team at Power has classified the safety of cannabis oil with a high ratio of CBD to THC as a 1, since this is an early phase trial and limited data exists regarding its efficacy or security."
Am I eligible to take part in this clinical study?
"This trial seeks 12 individuals aged 19 to 35 who present as medically healthy. Further, enrollees must have an average Cannabidiol (CBD) intake of at least 50 milligrams and Delta-9-tetrahydrocannabinol (THC) consumption of 10 mg or greater. Additionally, the study requires participants to be exposed to one or more from a list that includes Cocaine, crack cocaine, Methylenedioxymethamphetamine (MDMA/ecstasy/molly), Methamphetamine (meth, ice/crystal meth, speed), Amphetamine (Adderall), Amphetamine/d"
What are the primary desired outcomes of this research initiative?
"This medical research seeks to measure how often adverse events and subjective effects occur between sessions. It also looks into differences in responses on drug effect questionnaires, standardized mood profiles, and behavioural impulsivity tasks."
Does this clinical trial accommodate individuals younger than 45 years of age?
"Patients aged 19 to 35 fulfil the eligibility requirements of this experiment; there are 65 studies for participants under 18 years old and 417 trials focused on those who have exceeded retirement age."
Are there any vacancies for participants in this clinical experiment?
"The trial, which was initially uploaded on November 1st 2022 and last modified October 17th of the same year, is no longer searching for people to participate. Despite this, 952 other clinical trials are presently recruiting participants."
Who else is applying?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How responsive is this trial?
Typically responds via
Most responsive sites:
- B.R.A.I.N. Lab, Institute of Mental Health, Faculty of Medicine, University of British Columbia: < 48 hours
Average response time
- < 2 Days
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