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Cancer Vaccine
Vaccine + Ganciclovir for Mesothelioma
Phase 1
Waitlist Available
Research Sponsored by Louisiana State University Health Sciences Center in New Orleans
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
No prior malignancy except squamous or basal cell carcinoma of the skin
Histologically confirmed stage I, II, or III malignant mesothelioma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying vaccine therapy given together with ganciclovir to see how well it works in treating patients with mesothelioma.
Who is the study for?
This trial is for patients with early-stage malignant mesothelioma (stages I-III) who have a good performance status and normal organ function. They must not have severe heart or lung disease, no recent heart attacks, and no other cancers except certain skin cancers. Pregnant individuals or those on steroids can't participate.Check my eligibility
What is being tested?
The study is testing the combination of a vaccine made from the patient's own modified cancer cells and Ganciclovir to see if it helps treat mesothelioma by making the cancer more sensitive to this antiviral medication.See study design
What are the potential side effects?
Possible side effects may include reactions at the injection site due to the vaccine, as well as typical Ganciclovir-related issues like fever, rash, liver enzyme changes, blood disorders that could lead to infections or bleeding problems.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have had skin cancer but no other types of cancer.
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My mesothelioma is confirmed and not in the most advanced stage.
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My chest can safely accommodate a tube or catheter.
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I have not had a heart attack in the last 6 months.
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I do not need daily treatment for heart failure.
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My lung function is not severely reduced.
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I do not experience frequent chest pain.
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I do not have a history of serious heart problems.
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I am fully active or can carry out light work.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
Louisiana State University Health Sciences Center in New OrleansLead Sponsor
114 Previous Clinical Trials
44,201 Total Patients Enrolled
Paul O. Schwarzenberger, MDStudy ChairLouisiana State University Health Sciences Center in New Orleans
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had skin cancer but no other types of cancer.My chest can safely accommodate a tube or catheter.My mesothelioma is confirmed and not in the most advanced stage.It has been over 6 weeks since my last radiation treatment.I have not had a heart attack in the last 6 months.I do not need daily treatment for heart failure.My lung function is not severely reduced.I do not experience frequent chest pain.I do not have a history of serious heart problems.It has been over 6 weeks since my last chemotherapy session.I am not currently taking any steroids.My age does not affect my eligibility.I am fully active or can carry out light work.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is recruitment still underway for this research project?
"The clinical trial, first listed on August 1st 1997 and last updated September 19th 2013, is no longer recruiting patients. Luckily, there are 152 other trials actively looking for participants right now."
Answered by AI
What adverse effects can be expected from this therapeutic regimen?
"This being a phase 1 trial, with limited data regarding efficacy and safety, our team at Power assessed the treatment's security to be rated as 1 on a scale of 3."
Answered by AI
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