← Back to Search

Anti-metabolites

Tafasitamab for Diffuse Large B-Cell Lymphoma

Phase 1
Waitlist Available
Research Sponsored by MorphoSys AG
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months approximately
Awards & highlights

Study Summary

This trial is testing a new antibody to treat DLBCL in adults who have not been treated before. The antibody will be given with either R-CHOP or R-CHOP plus Lenalidomide.

Eligible Conditions
  • Diffuse Large B-Cell Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months approximately
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months approximately for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence and severity of treatment-emergent adverse events (TEAEs)
Secondary outcome measures
Anti-tafasitamab antibodies formation
Best Objective Response Rate (ORR) until the end of study
Event-free survival (EFS) at 12 and 24 months
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Arm BExperimental Treatment1 Intervention
Tafasitamab plus lenalidomide in addition to R-CHOP
Group II: Arm AExperimental Treatment1 Intervention
Tafasitamab in addition to R-CHOP
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tafasitamab
2016
Completed Phase 2
~180
Tafasitamab plus lenalidomide
2019
Completed Phase 1
~70

Find a Location

Who is running the clinical trial?

MorphoSys AGLead Sponsor
26 Previous Clinical Trials
6,594 Total Patients Enrolled
Pia Kloepfer, MDStudy DirectorMorphoSys AG
1 Previous Clinical Trials
864 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there extant research projects concerning the combination of Tafasitamab and lenalidomide?

"Tafasitamab plus lenalidomide was first trialled in 2004 at the Midwest Center for Hematology Oncology. Since then, 349 additional studies have been concluded with 272 presently recruiting patients; a notable concentration of them being conducted from Rockville, Maryland."

Answered by AI

What are the principal applications of Tafasitamab in conjunction with lenalidomide?

"Tafasitamab in combination with lenalidomide is principally used as a third-line cancer therapy after two prior systemic chemotherapy regimens. It has also been demonstrated to attenuate the effects of certain rare conditions such as amyloidosis, b-cell lymphomas and muscular dystrophy."

Answered by AI

What is the extent of enrollment in this medical experiment?

"Unfortunately, this research trial is not open for recruitment at the moment. It was initially posted on December 11th 2019 and it's latest update occurred on April 25th 2022. That being said, there are currently 1766 studies actively accepting lymphoma patients, as well as 272 clinical trials recruiting those with Tafasitamab plus lenalidomide."

Answered by AI

Are new participants being enrolled for this research project?

"Unfortunately, this clinical trial is currently not recruiting individuals. The investigation was first posted in December 11th of 2019 and has since been edited on April 25th of 2022. Nevertheless there are 1766 studies for lymphoma patients actively seeking candidates as well as 272 trials that involve tafasitamab plus lenalidomide looking for participants."

Answered by AI

How many medical institutions are participating in this research endeavor?

"This clinical trial is being held at 23 different sites, including cities like Rockville, Dallas and Austin. To reduce travel needs during the study, it's recommended to select the closest medical centre available."

Answered by AI

Has the combination of Tafasitamab and lenalidomide been granted clearance by the FDA?

"A score of 1 was assigned for the safety rating of Tafasitamab plus lenalidomide due to this being an early-stage trial with limited data available on efficacy and risks."

Answered by AI
~12 spots leftby Apr 2025