Power training for Depression

Phase-Based Estimates
Medical University of South Carolina, Charleston, SC
Depression+2 More
Power training - Behavioral
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether a 12 week strength training program can help treat depression and improve walking function for individuals who have had a stroke.

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Eligible Conditions

  • Depression
  • Melancholia
  • Stroke
  • Depressive Disorder

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Power training will improve 1 primary outcome and 1 secondary outcome in patients with Depression. Measurement will happen over the course of Visit 1 through visit 24 (up to 12 weeks).

Week 12
Change in Mean Score of Depression as Assessed by the Hamilton Rating Scale for Depression
Change in Self Selected Walking Speed

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

POWER training

This trial requires 48 total participants across 2 different treatment groups

This trial involves 2 different treatments. Power Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

POWER training
high velocity strength training
Upper and lower body range of motion exercises

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: visit 1 through visit 24 (up to 12 weeks)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly visit 1 through visit 24 (up to 12 weeks) for reporting.

Who is running the study

Principal Investigator
C. G.
Chris Gregory, PhD
Medical University of South Carolina

Closest Location

Medical University of South Carolina - Charleston, SC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-0.8 m/s
no antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)
HRSD question #9 regarding suicide <2; and 7) provision of informed consent.
age 50-70
stroke within the past 6 to 60 months
residual paresis in the lower extremity (Fugl-Meyer LE motor score <34)

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for depression?

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This overview of medications for depression contains a mixture of traditional antidepressants and newer and oft-studied agents that may be used as alternatives in patients who cannot tolerate traditional antidepressants. The paper also describes new classes of antidepressants, including the serotonin selective reuptake inhibitors (SSRIs).

Unverified Answer

What causes depression?

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Recent findings suggests that a combination of biological and psychological factors is the basis for the development of depression. However, while acknowledging the importance of the genetic inheritance element, the combination of biological factors and psychological traits are very important in determining the onset of depression.

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What are the signs of depression?

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Depression is an illness in its own right. It is important that patients understand the different symptoms of depression as well as to know potential cures. It is more important to treat depression than to mask or eliminate its symptoms. As there are no'standard' symptoms, diagnosis is often made long before symptoms appear or only after symptoms have been brought on by stress and illness. Although the general public may view depression as a'mood' or a'sickness' in itself, depression is a medical illness.

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How many people get depression a year in the United States?

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As the year progresses in the U.S., the percentage of people going to be depressed in the year 2005 increases to 2.3 times. Therefore, it is not unusual for a person to be going through a depressive episode. There have been no consistent studies on depression on an annual basis and there is no information to the public to determine if there is an increase in depressed people coming through the United States each year or not.

Unverified Answer

Can depression be cured?

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The treatment of depression can be challenging because people are sometimes reluctant to accept help or to believe that the problem isn't due to bad events. Patients are often afraid that treatment will make feelings worse, or that treatment won't really change things. However, most people who receive treatment do better. Many of your symptoms will improve, and will never be exactly like they were before treatment, but you'll be more like what you were before treatment. We can help you get better, but you can do it on your own.

Unverified Answer

What is depression?

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Depression is a common condition in which an inability to experience positive mood is seen alongside a decrease in intensity, duration, and frequency of positive mood. The condition usually begins between the ages of 10 and 30 and only very rarely continues into old age.

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What does power training usually treat?

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The combination treatment program resulted in greater improvements in both body composition and physiological exercise performance than placebo, which may represent a valuable treatment option for those with T2DM and a higher BMI.

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What is power training?

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The main issue was low intensity and low motivation. In our case the best result was due to having four training sessions per week with the therapist with great motivation. We could have gotten more out of each session but the therapist could have made clearer mistakes. We did not know what all our physical exercises, besides the one we knew, were. We did not take into account that training will not guarantee an overnight improvement like a real therapy. In that case we went back to seeing the psychologist and did whatever it was that worked (therapy of the therapist) for us at that moment.

Unverified Answer

Does depression run in families?

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Depressive symptoms are more frequently reported among family members of depressed patients than in the general population and are also associated with a lower overall quality of life.

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What are the common side effects of power training?

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All of the data showed that muscle swelling is a common side effect associated with high-intensity exercise. Moreover, a positive correlation was found between muscle swelling and fat layer growth. Therefore, we suggest that exercise, especially a high-intensity type such as power training, may cause a positive effect on both physical side effects and psychological effects.

Unverified Answer

How serious can depression be?

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Individuals with a chronic depression often perceive that their depressive disorders and/or the depressive symptoms they experience are severe enough to prevent them from leading a normal life and making normal day-to-day living a normal daily life. Therefore, depressive disorders are often misinterpreted as something that affects a person's life more seriously and more significantly than they realize\n

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Is power training typically used in combination with any other treatments?

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The findings suggest that power training appears to be effective in improving depressive symptoms and is a useful addition to conventional treatment for moderate to severe depression, particularly in those patients for whom antidepressant medication is contraindicated.

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