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Resistance Training

Strength Training for Post-Stroke Recovery (POWER-D Trial)

Phase 2
Recruiting
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)
Age 50-70
Timeline
Screening 3 weeks
Treatment Varies
Follow Up visit 1 through visit 24 (up to 12 weeks)
Awards & highlights

POWER-D Trial Summary

This trial will study if a 12 week strength training program helps treat depression and improves walking function in individuals who have had a stroke.

Who is the study for?
This trial is for individuals aged 50-70 who had a stroke within the last 5 years, can walk without help at certain speeds, and are experiencing depression. They shouldn't have made any recent changes to antidepressant medication or be on such treatments. People with uncontrolled diabetes, severe heart conditions, other major neurological disorders, or those at risk of suicide aren't eligible.Check my eligibility
What is being tested?
The study tests if a 12-week strength training program (power training) versus stretching exercises can improve walking function and alleviate depression in post-stroke patients. The goal is to develop better treatment strategies for common post-stroke issues.See study design
What are the potential side effects?
While not explicitly stated, potential side effects may include muscle soreness or injury from power training and fatigue. Stretching could cause discomfort if not done properly. Participants will be monitored for any adverse reactions.

POWER-D Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I haven't started or changed any antidepressant doses in the last 4 weeks.
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I am between 50 and 70 years old.
Select...
I had a stroke between 6 months and 5 years ago.
Select...
I can walk on my own without help or devices at various speeds.
Select...
I have weakness in my leg (Fugl-Meyer score <34).
Select...
I am between 50 and 70 years old.
Select...
I have weakness in my leg.
Select...
I can walk on my own without help or devices at a slow to moderate pace.

POWER-D Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~visit 1 through visit 24 (up to 12 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and visit 1 through visit 24 (up to 12 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mental Depression
Secondary outcome measures
Change in Self Selected Walking Speed

POWER-D Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: POWER trainingExperimental Treatment1 Intervention
high velocity strength training
Group II: StretchingActive Control1 Intervention
Upper and lower body range of motion exercises
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Power training
2021
N/A
~70

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
930 Previous Clinical Trials
7,393,763 Total Patients Enrolled
40 Trials studying Depression
6,905 Patients Enrolled for Depression
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,953 Previous Clinical Trials
2,660,432 Total Patients Enrolled
29 Trials studying Depression
15,351 Patients Enrolled for Depression

Media Library

Power training (Resistance Training) Clinical Trial Eligibility Overview. Trial Name: NCT03826771 — Phase 2
Depression Research Study Groups: POWER training, Stretching
Depression Clinical Trial 2023: Power training Highlights & Side Effects. Trial Name: NCT03826771 — Phase 2
Power training (Resistance Training) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03826771 — Phase 2
Depression Patient Testimony for trial: Trial Name: NCT03826771 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research protocol admit participants who are aged 65 and older?

"The age range for inclusion in this medical experiment is between 50 and 70 years old."

Answered by AI

Is there presently an enrollment opportunity for participants?

"Clinicaltrials.gov states that enrollment is still open for this study, which was initially available on February 6th 2019 and most recently updated November 2nd 2022."

Answered by AI

How many participants are receiving treatment as part of this clinical trial?

"Affirmative. The information on clinicaltrials.gov substantiates that this medical experiment is actively recruiting participants, which began its recruitment process on February 6th 2019 and was recently edited on November 2nd 2022. Currently, 48 individuals are needed from one site for the research to be carried out successfully."

Answered by AI

What risks can be attributed to the implementation of Power training for patients?

"In-depth data regarding the safety of Power training has been accrued, resulting in an overall score of 2 on our risk assessment scale. Phase two trials have established some evidence for its safety but no efficacy yet."

Answered by AI

Who is eligible for enrolment in this experiment?

"To gain entry to this medical trial, applicants must have depression and reside within the ages 50-70. This research is expected to bring in about 48 participants."

Answered by AI

Who else is applying?

What state do they live in?
South Carolina
What site did they apply to?
Medical University of South Carolina
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have chronic depression and anxiety with suicidal tendencies.
PatientReceived 1 prior treatment
~8 spots leftby Mar 2025