MOv19-BBz CAR T cells for Ovarian Cancer

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Pennsylvania Health System, Philadelphia, PAOvarian Cancer+2 MoreMOv19-BBz CAR T cells - Drug
Eligibility
18+
Female
What conditions do you have?
Select

Study Summary

This trial is testing a new type of cancer treatment involving genetically modified immune cells.

Eligible Conditions
  • Ovarian Cancer
  • Primary Peritoneal Carcinoma

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: 15 years

15 years
Number of study subjects with treatment-related adverse events using NCI Common Terminology Criteria for Adverse Events (CTCAE) v5.0
Overall survival (OS)
5 years
Overall response rates (ORR)
Progression-free survival (PFS)
Month 6
Tumor response rates measured according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) criteria

Trial Safety

Safety Progress

1 of 3

Trial Design

4 Treatment Groups

Cohort 3: MOv19-BBz CAR T cells after chemo
1 of 4
Cohort-1: without chemo;only if dose de-escalation required
1 of 4
Cohort 1: MOv19-BBz CAR T cells without chemo
1 of 4
Cohort 2: MOv19-BBz CAR T cells after chemo
1 of 4

Experimental Treatment

18 Total Participants · 4 Treatment Groups

Primary Treatment: MOv19-BBz CAR T cells · No Placebo Group · Phase 1

Cohort 3: MOv19-BBz CAR T cells after chemoExperimental Group · 2 Interventions: Alpha Folate Receptor expression test, MOv19-BBz CAR T cells · Intervention Types: Device, Drug
Cohort-1: without chemo;only if dose de-escalation requiredExperimental Group · 2 Interventions: Alpha Folate Receptor expression test, MOv19-BBz CAR T cells · Intervention Types: Device, Drug
Cohort 1: MOv19-BBz CAR T cells without chemoExperimental Group · 2 Interventions: Alpha Folate Receptor expression test, MOv19-BBz CAR T cells · Intervention Types: Device, Drug
Cohort 2: MOv19-BBz CAR T cells after chemoExperimental Group · 2 Interventions: Alpha Folate Receptor expression test, MOv19-BBz CAR T cells · Intervention Types: Device, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 15 years

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
1,869 Previous Clinical Trials
41,146,384 Total Patients Enrolled
10 Trials studying Ovarian Cancer
988 Patients Enrolled for Ovarian Cancer
Payal D Shah, MDPrincipal InvestigatorUniversity of Pennsylvania

Eligibility Criteria

Age 18+ · Female Participants · 9 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

Are participants currently being enrolled in this research?

"As per the details provided on clinicaltrials.gov, this research is currently enrolling individuals into its study group. The trial was initially posted in October 2018 and has recently been updated as of September 2022." - Anonymous Online Contributor

Unverified Answer

Has the FDA granted approval to MOv19-BBz CAR T cells?

"MOv19-BBz CAR T cells have limited clinical data to support their safety and efficacy, so they were assigned a score of 1." - Anonymous Online Contributor

Unverified Answer

What is the sample size of participants enrolled in this experiment?

"Affirmative. According to the data hosted on clinicaltrials.gov, this medical trial is actively recruiting patients that were first mentioned in October 2018 and recently updated in September 2022. The study requires 18 individuals from 1 centre for participation." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.