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Cancer Vaccine

Colorectal Cancer Peptide Vaccine PolyPEPI1018 for Colorectal Cancer

Phase 1
Waitlist Available
Led By Mojun Zhu, M.D.
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year
Awards & highlights

Study Summary

This trial is testing a combination of two treatments: a vaccine and a drug. The vaccine is designed to activate the body's immune cells to fight the cancer, and the drug is designed to help block the formation of new cancer growths. The goal is to see if this combination can kill more cancer cells in patients with metastatic colorectal cancer.

Eligible Conditions
  • Metastatic Colorectal Cancer
  • Rectal Cancer
  • Colorectal Cancer
  • Colon Cancer
  • Rectal Carcinoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of adverse events (AE)
Secondary outcome measures
Duration of response (DoR)
Overall response rate (ORR)
Overall survival (OS)
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (PolyPEPI1018, TAS-102)Experimental Treatment2 Interventions
Patients receive PolyPEPI1018 SC at 4 injection sites on days 1 and 15 and trifluridine and tipiracil hydrochloride PO BID on days 1-5 and 8-15. Treatment repeats every 28 days for up to 7 cycles in the absence of disease progression or unacceptable toxicity.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Colorectal Cancer Peptide Vaccine PolyPEPI1018
2022
Completed Phase 1
~20
Trifluridine and Tipiracil Hydrochloride
2019
Completed Phase 2
~70

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,657 Previous Clinical Trials
40,933,652 Total Patients Enrolled
Mayo ClinicLead Sponsor
3,206 Previous Clinical Trials
3,767,068 Total Patients Enrolled
Mojun Zhu, M.D.Principal InvestigatorMayo Clinic in Rochester
1 Previous Clinical Trials
45 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many subjects are partaking in this research endeavor?

"Affirmative. Information from clinicaltrials.gov indicates that this research project is actively trying to gather participants, with the first post being made on January 10th 2022 and last updated on the same date. Specifically, 15 individuals are needed for a single trial site."

Answered by AI

Has the Colorectal Cancer Peptide Vaccine PolyPEPI1018 achieved regulatory clearance from the FDA?

"Considering the limited safety and efficacy data, our team at Power has given Colorectal cancer Peptide Vaccine PolyPEPI1018 a score of 1 on their scale."

Answered by AI

Is this experiment accessible to participants at the current time?

"According to clinicaltrials.gov, this medical trial is currently enrolling new participants and has been since January 10th 2022 when it was first posted. The study's information was most recently updated on the same date."

Answered by AI

Could you provide any information on previous experiments involving Colorectal Cancer Peptide Vaccine PolyPEPI1018?

"Presently, 43 different clinical trials researching Colorectal cancer Peptide Vaccine PolyPEPI1018 are ongoing. 4 of the active studies have entered Phase 3 and all originate from Lakewood, New jersey; however, 527 sites around the world are running these tests."

Answered by AI

Is this research the inaugural study of its type?

"Since 2017, the research of Colorectal cancer Peptide Vaccine PolyPEPI1018 has continued to gain traction. The initial study was sponsored by Taiho Oncology and encompassed 56 participants. Upon successful completion of Phase 1 & 2 trials, 43 studies have sprung up in 235 cities and 28 countries worldwide."

Answered by AI

For what clinical applications is Colorectal Cancer Peptide Vaccine PolyPEPI1018 used?

"Patients diagnosed with ocular vaccinia infection, who have previously been administered oxaliplatin chemotherapy and anti-vegf treatment, can be aided using the Colorectal cancer Peptide Vaccine PolyPEPI1018."

Answered by AI
~5 spots leftby Apr 2025