Your session is about to expire
← Back to Search
Botensilimab + Balstilimab for Colorectal Cancer
Study Summary
This trial tests a new drug to fight colorectal cancer that has not responded to other treatments.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- I have an uncontrolled HIV infection.My condition causes fluid buildup in my abdomen that is hard to treat.I have had an organ, stem cell, or bone marrow transplant.I have an active heart condition.I need medication that affects liver enzymes.My tumor is MSI-H/dMMR as confirmed by a test.I am currently experiencing active bleeding symptoms.I have wounds that are not healing.I haven't received growth factors, transfusions, or albumin in the last 14 days.I haven't taken specific drugs recently before starting the trial.I have had a bowel blockage or symptoms of one in the last 3 months.I haven't needed systemic treatment for an autoimmune disease in the last 2 years.I don't have any health issues that would affect the study or stop me from participating fully.My organs are working well.I am fully active or can carry out light work.I have had at least one chemotherapy treatment for my cancer that has returned or spread.I have been treated with regorafenib or trifluridine/tipiracil.I have or had lung inflammation or scarring that needed steroids.My colorectal cancer cannot be removed by surgery and has spread.I don't have any other cancers needing treatment or that were active in the last 2 years, except for certain low-risk or treated skin, prostate, or noninvasive cancers.My scans show cancer has spread to my liver.I had a mild or no symptom COVID-19 infection within the last 10 days or a severe one within the last 20 days.My tumor was tested for MSI-H or dMMR status.I haven't taken high-dose steroids or immunosuppressants recently.I have a gut condition that could affect how I absorb medication.My high blood pressure is not controlled by medication.I agree to use effective birth control during and up to 6 months after the study.I have an active hepatitis C infection confirmed by tests.I have brain metastases but meet the specific exceptions.I have received treatments targeting my immune system to fight cancer.
- Group 1: Monotherapy Botensilimab Dose 2
- Group 2: Monotherapy Botensilimab Dose 1
- Group 3: Standard of Care
- Group 4: Combination Botensilimab Dose 1 plus Balstilimab
- Group 5: Combination Botensilimab Dose 2 plus Balstilimab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the FDA's thoughts on Botensilimab in conjunction with Balstilimab?
"While there is some data supporting the safety of this combination of Botensilimab (Dose 1) and Balstilimab, it only received a 2 because there are no Phase 2 trials demonstrating efficacy."
Is this trial popular in North America?
"Patients can enroll at HonorHealth Research Institute in Scottsdale, Arizona; Lifespan Clinical Research Center/Cancer Institute (Providence Rhode island) in East Providence, Rhode Island; Mount Sinai Hospital - New york in New York, New York or one of the 26 other facilities."
Are there any available positions for test subjects in this clinical trial?
"The listed clinical trial on clinicaltrials.gov is not recruiting patients at this time. The study was posted on 11/1/2022 and has not been updated since. However, 894 other trials are actively looking for candidates right now."
Share this study with friends
Copy Link
Messenger