EAAT2 PET Tracer for Dementia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new imaging agent that can be seen with a PET scan to detect early brain changes in patients with Alzheimer's disease and frontotemporal dementia. The agent targets a specific brain protein that is less active in these diseases. By identifying these changes early, doctors hope to improve diagnosis and treatment.
Will I have to stop taking my current medications?
Yes, you must stop taking any central nervous system (CNS) prescription drugs for three weeks before participating in the trial.
How does the EAAT2 PET tracer treatment for dementia differ from other treatments?
The EAAT2 PET tracer for dementia is unique because it focuses on imaging a specific protein involved in brain function, which may help in diagnosing and understanding dementia. Unlike traditional treatments that aim to alleviate symptoms, this tracer is used for diagnostic imaging to observe brain changes, potentially leading to more targeted therapies in the future.12345
What data supports the effectiveness of the drug [18F]RP-115 for dementia?
The research highlights the use of PET imaging with various tracers, like [18F] AV-45, in diagnosing Alzheimer's disease and other dementias. These tracers help visualize brain changes, such as amyloid protein buildup, which are important for early diagnosis and understanding dementia. While [18F]RP-115 is not directly mentioned, similar tracers have shown effectiveness in studying dementia-related brain changes.16789
Who Is on the Research Team?
David Wilson, MD, PhD
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
This trial is for adults aged 40-75 with suitable arteries for catheterization, non-smokers, not on CNS drugs for three weeks, and those who can consent or have a guardian to do so. Pregnant or breastfeeding individuals and those with certain medical devices or conditions that could affect the study's outcome are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dosimetry and Safety Assessment
Whole-body PET/MRI scan conducted immediately after [18F]RP-115 injection to establish safety and dosimetry in healthy volunteers
Diagnostic Performance Evaluation
Utilize [18F]RP-115 to assess regional cerebral binding differences in healthy volunteers compared to AD and FTD patients
Follow-up
Participants are monitored for safety and effectiveness after treatment, including a follow-up 24-48 hours after [18F]RP-115 administration
What Are the Treatments Tested in This Trial?
Interventions
- [18F]RP-115
Find a Clinic Near You
Who Is Running the Clinical Trial?
David Wilson
Lead Sponsor
Rio pharmaceuticals Inc.
Collaborator