Huntington's Disease Clinical Trials
Huntington's Disease studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect huntington's disease clinical trial.
Condition
Huntington's Disease
Location
Distance
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Clinical Trials
Huntington's Disease Clinical Trials
1
Effectiveness
2
Safety
PTC518
for Huntington Disease
Washington, United States
18+
All Sexes
Phase 2
Recruiting
Washington, United States
18+
All Sexes
The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 and placebo in participants with HD.
1
Effectiveness
1
Safety
Active TDCS
for Neurobehavioral Manifestations
Houston, TX
18+
All Sexes
Waitlist Available
Stage III
Houston, TX
18+
All Sexes
The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms
1
Effectiveness
1
Safety
Movement To Music
for Huntington Disease
Columbus, OH
18+
All Sexes
Recruiting
Columbus, OH
18+
All Sexes
The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1). A secondary aim will be to determine if a movement to music exercise program delivered via telehealth improves balance, cognition, mobility, and quality of life (Aim 2).
1
Effectiveness
1
Safety
MindTrails
for Etat Marbre
Charlottesville, VA
18+
All Sexes
Waitlist Available
Charlottesville, VA
18+
All Sexes
The purpose of this study is conduct a pilot open trial of a web-based cognitive bias modification intervention to reduce anxiety symptoms in persons with Huntington's disease and persons with Parkinson's disease.
1
Effectiveness
2
Safety
Branaplam
for Huntington Disease
New York, NY
18+
All Sexes
Phase 2
Recruiting
Stage I
New York, NY
18+
All Sexes
This is the first study of branaplam in adults with Huntington's Disease (HD) to determine the correct dose required to lower mutant huntingtin protein (mHTT) levels in the cerebrospinal fluid (CSF) to a degree expected to be efficacious over longer periods of time.
1
Effectiveness
2
Safety
SAGE-718
for Huntington Disease
Englewood, CO
18+
All Sexes
Phase 2
Recruiting
Englewood, CO
18+
All Sexes
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance and functioning in participants with HD.
1
Effectiveness
1
Safety
WVE-003
for Huntington Disease
Ottawa, Canada
18 - 65
All Sexes
Phase 1 & 2
Recruiting
Ottawa, Canada
18 - 65
All Sexes
This study is evaluating whether a drug called WVE-003 can slow the progression of Huntington's disease.
1
Effectiveness
2
Safety
Deutetrabenazine
for Huntington Disease
Nashville, TN
18+
All Sexes
Phase 2 & 3
Recruiting
Nashville, TN
18+
All Sexes
Examine the effects of deutetrabenazine on functional speech and gait impairment
2
Effectiveness
3
Safety
Pridopidine
for Huntington Disease
Vancouver, Canada
18+
All Sexes
Phase 3
Waitlist Available
Stage I
Vancouver, Canada
18+
All Sexes
This study is evaluating whether a drug may help reduce symptoms of Huntington's disease.
1
Effectiveness
1
Safety
Melatonin
for Huntington Disease
Houston, TX
18+
All Sexes
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether melatonin may help improve sleep quality for individuals with Huntington's disease.
1
Effectiveness
2
Safety
BioStamp NPoint Device
for Huntington Disease
Rochester, NY
18+
All Sexes
Phase 2
Recruiting
Rochester, NY
18+
All Sexes
This study is evaluating whether risperidone may help reduce involuntary movements in individuals with Huntington's disease.
1
Effectiveness
1
Safety
Intra-striatal RAAV5-miHTT
for Huntington Disease
Baltimore, MD
18+
All Sexes
Phase 1 & 2
Recruiting
Baltimore, MD
18+
All Sexes
This study is evaluating whether a drug may help reduce symptoms of Huntington's disease.
2
Effectiveness
3
Safety
Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg)
for Huntington Disease
Houston, TX
18+
All Sexes
Phase 3
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether a drug may help reduce irritability in individuals with Huntington's disease.
2
Effectiveness
3
Safety
RO7234292 (RG6042)
for Huntington Disease
Englewood, CO
18+
All Sexes
Phase 3
Waitlist Available
Englewood, CO
18+
All Sexes
This study is evaluating the long-term safety and tolerability of a drug that is being developed for Huntington's disease.
1
Effectiveness
1
Safety
Nilotinib 150 MG
for Huntington Disease
Washington, United States
18+
All Sexes
Phase 1
Waitlist Available
Washington, United States
18+
All Sexes
This study is evaluating whether nilotinib may have positive impacts for individuals with Parkinson's disease.
2
Effectiveness
3
Safety
RO7234292
for Huntington Disease
Englewood, CO
18+
All Sexes
Phase 3
Waitlist Available
Englewood, CO
18+
All Sexes
This study will evaluate the efficacy, safety, and biomarker effects of RO7234292 (RG6042) compared with placebo in participants with manifest Huntington's disease (HD).
1
Effectiveness
1
Safety
Protocol Intervention Group
for Huntington Disease
Nashville, TN
18+
All Sexes
Recruiting
Nashville, TN
18+
All Sexes
Phase A: Recruit 50 patients with HD, and their caregivers, to complete a neuropsychiatric and quality of life battery of scales at baseline. Have these 50 patients complete a formal psychiatric assessment with a psychiatrist within 2 weeks of this clinical battery, and the results of these 2 types of assessments will be compared to establish the level of agreement between clinical rating scales and formal psychiatric assessment. Phase B: Continue to follow Phase A cohort longitudinally and administer neuropsychiatric and quality of life battery at 6 months, 12 months, and 18 months form baseline. Recruit an additional 50 patients, administer the same neuropsychiatric and quality of life battery at baseline, implement medication and counseling intervention according to a standard of care protocol, and follow up with the same neuropsychiatric and quality of life battery at 6, 12, and 18 months.
1
Effectiveness
1
Safety
Physical Activity
for Huntington Disease
Los Angeles, CA
18+
All Sexes
Waitlist Available
Los Angeles, CA
18+
All Sexes
Huntington's disease (HD) is a genetic, degenerative neurological disease that affects individuals in their third-fourth decade of life and individuals can live 15-20 years with manifest HD. The complex disease symptoms, including motor, cognitive and behavioural impairments, result in loss of functional independence and progressive escalation of healthcare costs. The personal, social and economic consequences of HD are devastating, especially as there are currently no disease modification therapies available. Environmental factors, including exercise and physical activity, have the potential to minimize the functional impact of HD. Animal models of HD have provided the first evidence that exercise has the potential to delay or alter disease progression. A range of studies in clinical populations have shown that short-term exercise (< 3 months) is well tolerated and has the potential to improve quality of life, fitness and motor impairments in HD. Despite these promising studies, there are critical knowledge gaps that prevent the intelligent application of exercise as a therapeutic intervention in HD. Firstly, there have been no prospective evaluations of the potential role of physical activity and exercise in disease modification in HD. To date, only retrospective data has suggested that lifestyle factors, including sedentary behavior, could negatively affect disease progression in HD. Secondly, it is not known if sustained exercise (> 3 months) is feasible, and if it has the potential to improve cognitive outcomes, such as has been shown in other neurodegenerative diseases. Such longer-term studies are essential to elucidate the potential for exercise to have a disease-modifying effect; the mechanisms through which such improvement may occur have yet to be explored. In this trial, the investigators will employ a systematic approach for routinely collecting prospective physical activity and fitness data and monitoring physical activity behaviour in 120 individuals with HD. The investigators will use a database to track physical activity and exercise behaviour alongside standardized disease-specific outcome measures during two annual visits. Assessment will incorporate VO2max, a surrogate measure of fitness and a direct measure of oxygen uptake related to central nervous system (CNS) function and structure, and the use of wearable technologies (Gene-activ activity monitors) that capture and quantify dose (frequency, duration, intensity) of physical activity in a large HD cohort. The investigators will further conduct a within-cohort randomized control trial (RCT) of a 12-month exercise intervention in HD, comparing a supported structured aerobic exercise training program to activity as usual. This intervention will also incorporate a physical activity coaching program developed and evaluated by our group with a view to encouraging longer term exercise uptake.
1
Effectiveness
1
Safety
Retinal Imaging
for Neurodegenerative Diseases
Durham, NC
18+
All Sexes
Recruiting
Locally Advanced
Durham, NC
18+
All Sexes
This study is evaluating whether a new imaging technique can help detect early signs of neurodegenerative diseases.
3
Effectiveness
3
Safety
Tetrabenazine
for Huntington Disease
Houston, TX
18+
All Sexes
Phase 4
Recruiting
Houston, TX
18+
All Sexes
This study is evaluating whether a medicine commonly used to treat Huntington's disease may help reduce impulsivity in individuals with the disease.
1
Effectiveness
1
Safety
Far Infrared Radiation
for Huntington Disease
Toronto, Canada
Any Age
All Sexes
Phase 1
Waitlist Available
Toronto, Canada
Any Age
All Sexes
Huntington's disease (HD) is a fatal disease with profound neurological and behavioral features. HD is typically characterized by uncontrollable movements and psychological disturbances. This study will investigate the use of far infrared radiation for control, management and treatment of HD.
1
Effectiveness
1
Safety
Ursodiol
for Huntington Disease
Portland, OR
18+
All Sexes
Phase 1
Waitlist Available
Portland, OR
18+
All Sexes
The purpose of this study is to evaluate the safety of the drug ursodiol (ursodeoxycholic acid, UDCA) in people with Huntington's disease (HD) and to explore how the compound is processed by the body.
Other Trials to Consider
Transcranial Alternating Current Stimulation (tACS)
for Alzheimer Disease
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Boston, MA
18+
All Sexes
GZ402666
for Glycogen Storage Disease
1
Effectiveness
2
Safety
Phase 2 & 3
Waitlist Available
Dallas, TX
Any Age
All Sexes
PTC518
for Huntington Disease
1
Effectiveness
2
Safety
Phase 2
Recruiting
Washington, United States
18+
All Sexes
WVE-003
for Huntington Disease
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Ottawa, Canada
18 - 65
All Sexes
AAV9 BBP-812
for Canavan Disease
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Boston, MA
< 18
All Sexes
Ipilimumab
for Hodgkin Disease
1
Effectiveness
2
Safety
Phase 2
Recruiting
Locally Advanced
Boston, MA
18+
All Sexes
Intermittent Theta Burst Stimulation
for Alzheimer Disease
1
Effectiveness
1
Safety
Recruiting
Saint Paul, MN
18+
All Sexes
EHR CDS
for Alzheimer Disease
1
Effectiveness
1
Safety
Waitlist Available
Los Angeles, CA
18+
All Sexes
Active TDCS
for Neurobehavioral Manifestations
1
Effectiveness
1
Safety
Waitlist Available
Stage III
Houston, TX
18+
All Sexes
Advanced Treadmill Walking
for Parkinson Disease
1
Effectiveness
1
Safety
Recruiting
Stage I
Atlanta, GA
18+
All Sexes
Exercise
for Disease
1
Effectiveness
1
Safety
Waitlist Available
New York, NY
18 - 65
All Sexes
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