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Bile Acid

A for Huntington's Disease (UDCA-HD Trial)

Phase 1
Waitlist Available
Led By Penelope Hogarth, M.D.
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 35 days
Awards & highlights

UDCA-HD Trial Summary

The purpose of this study is to evaluate the safety of the drug ursodiol (ursodeoxycholic acid, UDCA) in people with Huntington's disease (HD) and to explore how the compound is processed by the body.

UDCA-HD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~35 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 35 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bile Acids
Safety measures (complete blood count, chemistry profile, electrocardiogram, urinalysis)
Tolerability measures (adverse event severity)

Side effects data

From 2004 Phase 3 trial • 596 Patients • NCT00200343
26%
Nasopharyngitis
5%
Diarrhoea NOS
3%
Chest discomfort
3%
Dizziness
3%
Arthralgia
3%
Cystitis NOS
3%
Back pain
3%
Headache
3%
Pruritus
2%
Upper respiratory tract inflammation
2%
Insomnia
2%
Nausea
2%
Abdominal pain NOS
2%
Dyspepsia
2%
Abdominal distention
2%
Constipation
2%
Abdominal pain upper
2%
Stomach discomfort
1%
Eczema
1%
Hepatic neoplasm malignant NOS
1%
Loose stools
1%
Appendicitis perforated
1%
Anorexia
1%
Lung cancer stage unspecified (excl metastatic tumours to lung)
1%
Stomatitis
1%
Malaise
1%
Oedema peripheral
1%
Cellulitis
1%
Sternal fracture
1%
Rash NOS
1%
Epistaxis
1%
Pharyngolaryngeal pain
1%
Pyrexia
1%
Calculus ureteric
1%
Colonic polyp
100%
80%
60%
40%
20%
0%
Study treatment Arm
150mg / Day
600mg / Day
900mg / Day

UDCA-HD Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: BExperimental Treatment1 Intervention
Group II: AExperimental Treatment1 Intervention
Group III: CPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Huntington Society of CanadaOTHER
1 Previous Clinical Trials
19 Total Patients Enrolled
Huntington Study GroupNETWORK
13 Previous Clinical Trials
8,769 Total Patients Enrolled
Oregon Health and Science UniversityLead Sponsor
973 Previous Clinical Trials
7,385,791 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Ursodiol in Huntington's Disease
2007. "Ursodiol in Huntington's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00514774.
All > Huntingtons Disease
~1 spots leftby Apr 2025
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