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Tyrosine Kinase Inhibitor

Group 1 for Huntington's Disease (Tasigna HD Trial)

Phase 1
Waitlist Available
Research Sponsored by Georgetown University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Written informed consent
Capable of providing informed consent and complying with study procedures. Subjects who are unable to provide consent may use a Legally Authorized Representative (LAR).
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Tasigna HD Trial Summary

This study is evaluating whether nilotinib may have positive impacts for individuals with Parkinson's disease.

Tasigna HD Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Tasigna HD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
CSF levels of biomarkers linked to Disease symptoms Chorea and behavioral symptoms
Number of participants experiencing any Adverse events and Serious Adverse Events
Number of participants tolerating the drug by the ability of remaining on treatment

Side effects data

From 2014 Phase 3 trial • 267 Patients • NCT01275196
28%
Thrombocytopenia
27%
Leukopenia
23%
Platelet count decreased
22%
Lipase increased
21%
White blood cell count decreased
19%
Nasopharyngitis
19%
Eyelid oedema
14%
Anaemia
14%
Neutropenia
14%
Diarrhoea
13%
Hypophosphataemia
13%
Rash
12%
Alanine aminotransferase increased
12%
Neutrophil count decreased
11%
Haemoglobin decreased
11%
Pyrexia
11%
Vomiting
11%
Nausea
10%
Upper respiratory tract infection
10%
Hypokalaemia
9%
Blood creatine phosphokinase increased
8%
Hypertriglyceridaemia
8%
Blood phosphorus decreased
8%
Face oedema
7%
Aspartate aminotransferase increased
7%
Arthralgia
7%
Cough
6%
Myalgia
6%
Blood bilirubin increased
6%
Dizziness
5%
Influenza
4%
Hyperglycaemia
3%
Headache
3%
Hyperbilirubinaemia
2%
Abdominal pain upper
2%
Bilirubin conjugated increased
2%
Low density lipoprotein increased
2%
Apolipoprotein B increased
2%
Gamma-glutamyltransferase increased
2%
Hypercholesterolaemia
1%
Oesophageal squamous cell carcinoma
1%
Ovarian rupture
1%
Thrombocytosis
1%
Anal abscess
1%
Ankle fracture
1%
Blast cell count increased
1%
Intervertebral disc protrusion
1%
Cervix carcinoma stage 0
1%
Non-Hodgkin's lymphoma recurrent
1%
Cerebral haemorrhage
1%
Hydrothorax
1%
Thrombocytopenic purpura
1%
Bone marrow failure
1%
Granulocytopenia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Imatinib 400 mg qd
Nilotinib 300 mg Bid

Tasigna HD Trial Design

1Treatment groups
Experimental Treatment
Group I: Group 1Experimental Treatment1 Intervention
Ten (10) participants will receive an oral dose of 150mg Nilotinib once daily for 3 months (group 1). If Nilotinib 150 mg per mouth daily dose is tolerated by the 1st group of 10 participants for 3 months, another 10 participants will receive an oral dose of 300mg Nilotinib once daily (group 2) for 3 months.

Find a Location

Who is running the clinical trial?

Georgetown UniversityLead Sponsor
341 Previous Clinical Trials
126,492 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~2 spots leftby Mar 2025