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Limited transthoracic echocardiogram (LTTE) for Trauma Bay Intubation

N/A
Waitlist Available
Led By Aron Depew, MD
Research Sponsored by Riverside University Health System Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up mortality (death) during hospital stay, not to exceed 30 days
Awards & highlights

Study Summary

Primary caregiver thoracic ultrasound (U/S) is a skill which is growing in utility in critical care. First introduced for volume assessment in nephrology and cardiology, it is now being researched in emergency and critical care. Data is still evolving in its use in initial trauma evaluation. Inferior vena cava (IVC) diameter correlates with outcome in trauma, but utility of its measurement on U/S in the emergency department still has some controversy. In trauma specifically, small studies suggests benefit to the use of U/S to predict volume status, and most of these data are from one author. It is not known if this can be applied more broadly. The prognostic value of findings on limited transthoracic echocardiogram (LTTE, SonoSite Ultrasound) has been studied in several small studies, and only one small randomized controlled trial has proven benefit to its use. Due to inter-rater reliability and the fact that all reports on credentialing of thoracic ultrasound use in the trauma bay are from one group, it is not known if it can be applied to all trauma populations. Research question: Does LTTE (SonoSite Ultrasound) predict mortality, emergency surgery, intensive care unit (ICU) stay, hospital stay, time on ventilator, number of transfusions, or renal failure as well as or better than other methods of organ perfusion? Hypotheses: Use of LTTE is associated with improved outcomes (less organ failure, decreased hospital and ICU stays, transfusions, and mortality). LTTE predicts mortality, emergency surgery, ICU stay, hospital stay, time on ventilator, number of and transfusions better than other methods of organ perfusion (tachycardia, hypotension, lactate, lactate clearance, creatinine, base deficit).

Eligible Conditions
  • Trauma Bay Intubation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~mortality (death) during hospital stay, not to exceed 30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and mortality (death) during hospital stay, not to exceed 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
length of stay in the intensive care unit
Secondary outcome measures
mortality (death)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Limited transthoracic echocardiogram (LTTE)Experimental Treatment1 Intervention
LTTE (SonoSite Ultrasound), which will be performed every 10 - 30 minutes, after each fluid challenge or transfusion, until two consecutive equivalent measurements are reached without fluid challenge or transfusion
Group II: Usual careActive Control1 Intervention
measurements on :blood pressure, heart rate, urine output, lactate, lactate clearance (after 6 hrs), base deficit, creatinine

Find a Location

Who is running the clinical trial?

Riverside University Health System Medical CenterLead Sponsor
3 Previous Clinical Trials
1,552 Total Patients Enrolled
Aron Depew, MDPrincipal InvestigatorRiverside University Health System Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~10 spots leftby May 2025