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Beta-blocker

Stopping Beta-Blockers After Coronary Artery Bypass Surgery (DROP-BB Trial)

N/A
Recruiting
Led By Arnar Geirsson, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants who underwent coronary artery bypass graft (CABG) surgery at Yale New Haven Hospital who presented to 1-month postoperative visit with ejection fraction >50% and in sinus rhythm at the time of hospital discharge or enrollment.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

DROP-BB Trial Summary

This trial will test whether it's safe to stop taking beta-blockers after coronary artery bypass surgery.

Who is the study for?
This trial is for patients who had coronary artery bypass surgery at Yale New Haven Hospital, showed up for their 1-month post-op visit, have a heart pumping strength (ejection fraction) over 50%, and were in normal heart rhythm when leaving the hospital or joining the study. It's not for those who had additional valve or aorta surgeries along with their bypass.Check my eligibility
What is being tested?
The study is looking into what happens if you stop taking beta-blocker meds after having coronary artery bypass surgery. Patients are randomly chosen to either keep taking or stop their beta-blockers to see how it affects them.See study design
What are the potential side effects?
Stopping beta-blockers suddenly can lead to increased heart rate, blood pressure changes, chest pain, and risk of heart complications. The exact side effects will be closely monitored throughout the trial.

DROP-BB Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I had CABG surgery at Yale New Haven Hospital, left with a good heart pump function, and a normal heart rhythm.

DROP-BB Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak oxygen consumption (VO2 max) to measure cardiorespiratory fitness
Secondary outcome measures
Adherence to medication and adjudication of endpoint
Change in activity level measured using the Veterans Specific Activity Questionnaire(VSAQ)
Change in fatigue measured using the Fatigue Assessment Scale (FAS)
+1 more

DROP-BB Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Withdrawing of beta-blockersExperimental Treatment1 Intervention
Discontinuation of all BB, and medication changes will be made at the 1-month clinic visit. A cardiopulmonary exercise test (CPET) will be performed 1 month after the randomization (2 months after CABG).
Group II: Continuation of beta-blocker regimenActive Control1 Intervention
Participants will continue with current standard of care on current beta-blocker regimen

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,843 Previous Clinical Trials
2,734,831 Total Patients Enrolled
Glenn Memorial FundUNKNOWN
Arnar Geirsson, MDPrincipal InvestigatorYale University

Media Library

Discontinuing all beta-blocker (Beta-blocker) Clinical Trial Eligibility Overview. Trial Name: NCT05414331 — N/A
Coronary Artery Bypass Surgery Research Study Groups: Continuation of beta-blocker regimen, Withdrawing of beta-blockers
Coronary Artery Bypass Surgery Clinical Trial 2023: Discontinuing all beta-blocker Highlights & Side Effects. Trial Name: NCT05414331 — N/A
Discontinuing all beta-blocker (Beta-blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05414331 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment still looking for more participants?

"This research is not currently enrolling patients, as per the information on clinicaltrials.gov. The listing was created on October 1st, 2022 and last updated 29 other trials are ongoing and actively recruiting participants."

Answered by AI
~135 spots leftby Dec 2024