Your session is about to expire
← Back to Search
Beta-blocker
Stopping Beta-Blockers After Coronary Artery Bypass Surgery (DROP-BB Trial)
N/A
Recruiting
Led By Arnar Geirsson, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Participants who underwent coronary artery bypass graft (CABG) surgery at Yale New Haven Hospital who presented to 1-month postoperative visit with ejection fraction >50% and in sinus rhythm at the time of hospital discharge or enrollment.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
DROP-BB Trial Summary
This trial will test whether it's safe to stop taking beta-blockers after coronary artery bypass surgery.
Who is the study for?
This trial is for patients who had coronary artery bypass surgery at Yale New Haven Hospital, showed up for their 1-month post-op visit, have a heart pumping strength (ejection fraction) over 50%, and were in normal heart rhythm when leaving the hospital or joining the study. It's not for those who had additional valve or aorta surgeries along with their bypass.Check my eligibility
What is being tested?
The study is looking into what happens if you stop taking beta-blocker meds after having coronary artery bypass surgery. Patients are randomly chosen to either keep taking or stop their beta-blockers to see how it affects them.See study design
What are the potential side effects?
Stopping beta-blockers suddenly can lead to increased heart rate, blood pressure changes, chest pain, and risk of heart complications. The exact side effects will be closely monitored throughout the trial.
DROP-BB Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I had CABG surgery at Yale New Haven Hospital, left with a good heart pump function, and a normal heart rhythm.
DROP-BB Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Peak oxygen consumption (VO2 max) to measure cardiorespiratory fitness
Secondary outcome measures
Adherence to medication and adjudication of endpoint
Change in activity level measured using the Veterans Specific Activity Questionnaire(VSAQ)
Change in fatigue measured using the Fatigue Assessment Scale (FAS)
+1 moreDROP-BB Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Withdrawing of beta-blockersExperimental Treatment1 Intervention
Discontinuation of all BB, and medication changes will be made at the 1-month clinic visit. A cardiopulmonary exercise test (CPET) will be performed 1 month after the randomization (2 months after CABG).
Group II: Continuation of beta-blocker regimenActive Control1 Intervention
Participants will continue with current standard of care on current beta-blocker regimen
Find a Location
Who is running the clinical trial?
Yale UniversityLead Sponsor
1,843 Previous Clinical Trials
2,734,831 Total Patients Enrolled
Glenn Memorial FundUNKNOWN
Arnar Geirsson, MDPrincipal InvestigatorYale University
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had surgery on my aorta and bypass surgery.I had surgery for both heart valve and bypass.I had CABG surgery at Yale New Haven Hospital, left with a good heart pump function, and a normal heart rhythm.
Research Study Groups:
This trial has the following groups:- Group 1: Continuation of beta-blocker regimen
- Group 2: Withdrawing of beta-blockers
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this experiment still looking for more participants?
"This research is not currently enrolling patients, as per the information on clinicaltrials.gov. The listing was created on October 1st, 2022 and last updated 29 other trials are ongoing and actively recruiting participants."
Answered by AI
Share this study with friends
Copy Link
Messenger