Discontinuing all beta-blocker for Coronary Artery Bypass Surgery

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Coronary Artery Bypass SurgeryDiscontinuing all beta-blocker - Other
Eligibility
18+
All Sexes
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Study Summary

This trial will test whether it's safe to stop taking beta-blockers after coronary artery bypass surgery.

Treatment Effectiveness

Effectiveness Progress

1 of 3

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1
OCT-guided saphenous vein CABG
1
Sonovein Treatment
2
Parasternal blocks

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: 12 months

1 month
Peak oxygen consumption (VO2 max) to measure cardiorespiratory fitness
12 months
Adherence to medication and adjudication of endpoint
baseline and 3 months
Change in activity level measured using the Veterans Specific Activity Questionnaire(VSAQ)
Change in fatigue measured using the Fatigue Assessment Scale (FAS)
Change in vertigo symptoms measured using the Vertigo Symptom Scale-short form

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
OCT-guided saphenous vein CABG
1
Sonovein Treatment
3
Parasternal blocks

Trial Design

2 Treatment Groups

Continuation of beta-blocker regimen
1 of 2
Withdrawing of beta-blockers
1 of 2

Active Control

Experimental Treatment

406 Total Participants · 2 Treatment Groups

Primary Treatment: Discontinuing all beta-blocker · No Placebo Group · N/A

Withdrawing of beta-blockers
Other
Experimental Group · 1 Intervention: Discontinuing all beta-blocker · Intervention Types: Other
Continuation of beta-blocker regimenNoIntervention Group · 1 Intervention: Continuation of beta-blocker regimen · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months

Who is running the clinical trial?

Glenn Memorial FundUNKNOWN
Yale UniversityLead Sponsor
1,678 Previous Clinical Trials
21,087,407 Total Patients Enrolled
Arnar Geirsson, MDPrincipal InvestigatorYale University
Makoto Mori, MDPrincipal InvestigatorYale University

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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References

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