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Integrated PTSD & Nightmare Therapy for Post-Traumatic Stress Disorder (CPTERRT Trial)

Led By Joanne l Davis, PhD
Research Sponsored by University of Tulsa
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
meet full criteria for PTSD
18 Years of Age minimal
Must not have
17 years of age or younger
Screening 3 weeks
Treatment Varies
Follow Up past month symptoms measured at baseline, and 3 and 6 month follow-up
Awards & highlights


This trial is studying a possible new treatment for PTSD that integrates exposure, relaxation, and rescripting therapy with cognitive processing therapy.

Who is the study for?
This trial is for adults who have experienced trauma, suffer from PTSD with at least one nightmare per week over the past month. It's not suitable for individuals under 18, those with active suicidal thoughts, recent substance abuse disorders, acute psychosis, bipolar disorder or intellectual disability.Check my eligibility
What is being tested?
The study tests if combining two therapies—Cognitive Processing Therapy (CPT) and Exposure, Relaxation and Rescripting Therapy (ERRT)—is more effective for treating PTSD and related nightmares than CPT alone. Participants will receive either both treatments in sequence or just CPT.See study design
What are the potential side effects?
Potential side effects may include increased distress due to recalling traumatic events during therapy sessions. As these are psychological interventions rather than medications, traditional physical side effects are not expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have been diagnosed with PTSD.
I am at least 18 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
I am 17 years old or younger.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~past month symptoms measured at baseline, and 3 and 6 month follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and past month symptoms measured at baseline, and 3 and 6 month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Nightmare Frequency
Secondary outcome measures
Clinician Administered PTSD Scale

Trial Design

3Treatment groups
Active Control
Group I: Cognitive Processing Therapy-CognitiveActive Control1 Intervention
12 sessions of cognitive processing therapy-Cognitive
Group II: CPT-C + ERRTActive Control2 Interventions
12 sessions of Cognitive Processing Therapy - Cognitive, followed by 5 sessions of Exposure, Relaxation, and Rescripting Therapy
Group III: ERRT + CPT-CActive Control2 Interventions
5 sessions of Exposure, Relaxation, and Rescripting Therapy, followed by 12 sessions of Cognitive Processing Therapy- Cognitive

Find a Location

Who is running the clinical trial?

University of TulsaLead Sponsor
15 Previous Clinical Trials
10,735 Total Patients Enrolled
Joanne l Davis, PhDPrincipal InvestigatorUniversity of Tulsa

Media Library

Cognitive Processing Therapy - Cognitive Clinical Trial Eligibility Overview. Trial Name: NCT02236390 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Cognitive Processing Therapy-Cognitive, CPT-C + ERRT, ERRT + CPT-C
Post-Traumatic Stress Disorder Clinical Trial 2023: Cognitive Processing Therapy - Cognitive Highlights & Side Effects. Trial Name: NCT02236390 — N/A
Cognitive Processing Therapy - Cognitive 2023 Treatment Timeline for Medical Study. Trial Name: NCT02236390 — N/A
~8 spots leftby Aug 2025