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Topical Zinc Compound for Sun-Damaged Skin

N/A

Waitlist Available

Research Sponsored by Integrative Skin Science and Research

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subjects must avoid professional or facial spa procedures during the study

Females between the ages of 40 years of age until 60 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 8 weeks

Awards & highlights

Study Summary

This trial tested a zinc compound on skin hydration, elasticity, water loss & microbiome to treat photoaged skin.

Who is the study for?

This trial is for women aged 40-60 with visible facial fine lines and wrinkles. They must avoid professional skin treatments, minimize sun exposure, and not use certain skincare products before the study. Excluded are pregnant or breastfeeding individuals, recent antibiotic users, those unable to consent, tobacco smokers with a significant history, and anyone who's had cosmetic facial treatments recently.Check my eligibility

What is being tested?

The study tests Zinc Di-(dibutyryl lisinate) (Z-DBL) applied topically against a placebo vehicle to see its effects on skin hydration, elasticity, water loss through the skin (transepidermal water loss), and changes in the skin microbiome in photoaged skin. It's a double-blind study where neither participants nor researchers know who receives Z-DBL or placebo.See study design

What are the potential side effects?

Potential side effects of topical Z-DBL are not specified but may include local reactions like redness or irritation at the site of application. Since it's being compared to a placebo vehicle cream that usually has no active ingredients, any unique side effects from Z-DBL should be noticeable.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I will not undergo any professional facial treatments during the study.

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I am a woman aged between 40 and 60.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in image analysis based pigment intensity

Skin Hydration

Secondary outcome measures

Change in image analysis based wrinkle severity

Change in skin elasticity

Change in skin transepidermal water loss

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Topical Vehicle + Zinc Di-(dibutyryl lisinate)Experimental Treatment1 Intervention

Topical cream containing Zinc Di-(dibutyryl listinate)

Group II: Topical VehiclePlacebo Group1 Intervention

Topical cream

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Sytheon Ltd.Industry Sponsor

6 Previous Clinical Trials

224 Total Patients Enrolled

1 Trials studying Solar Elastosis

32 Patients Enrolled for Solar Elastosis

Integrative Skin Science and ResearchLead Sponsor

31 Previous Clinical Trials

2,686 Total Patients Enrolled

6 Trials studying Solar Elastosis

267 Patients Enrolled for Solar Elastosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this scientific experiment seeking participants who are over three-quarters of a century old?

"Per the criteria for inclusion in this clinical trial, the lower age threshold is 40 and the upper limit is 60."

Answered by AI

Do I satisfy the requirements to be a potential contributor in this research project?

"To be considered for this clinical trial, potential participants must demonstrate solar elastosis and fall within the age bracket of 40 to 60 years old. Currently there is a need for 46 study subjects."

Answered by AI

Is there still an opportunity for individuals to enroll in this research endeavor?

"According to clinicaltrials.gov, the recruitment for this medical study has ceased as of October 17th 2023; while it is not currently looking for patients, there are 8 other trials that still require participants. This trial was initially posted on October 15th 2023."

Answered by AI

What aims has this medical experiment been established to fulfill?

"According to Integrative Skin Science and Research, the primary objective of this 8-week trial is assessing skin hydration. Furthermore, secondary outcomes are also being assessed such as shifts in the skin microbiome diversity (via whole genome sequencing), modifications in filaggrin levels (measured by D-Squame tape strips) and product tolerability (rated based on burning, stinging or scaling sensations)."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin

2023. "The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06096649.