CLINICAL TRIAL

Experimental feedback for Opioid Abuse

Recruiting · 18 - 65 · All Sexes · New Haven, CT

This study is evaluating whether neurofeedback training can help individuals with opioid use disorder.

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About the trial for Opioid Abuse

Eligible Conditions
Substance-Related Disorders · Opioid-Related Disorders

Treatment Groups

This trial involves 2 different treatments. Experimental Feedback is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Experimental feedback
DEVICE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
lowered overdose rates Methadone treatment for 3 or more months lowered the rates of overdoses. show original
The DSM-5 criteria for opioid use disorder, as assessed via the SCID, are as follows: 1 show original
and during follow-up The subject had a positive urine screen for opioids other than methadone during standard treatment or self-reported past-month opioid use at screening and during follow-up. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: baseline to one month post follow-up (up to 2 months).
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to one month post follow-up (up to 2 months).
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: baseline to one month post follow-up (up to 2 months)..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Experimental feedback will improve 1 primary outcome and 3 secondary outcomes in patients with Opioid Abuse. Measurement will happen over the course of Baseline through follow-up (4 weeks)..

2. Functional connectivity patterns in the brain
BASELINE THROUGH FOLLOW-UP (4 WEEKS).
This outcome will be assessed with functional magnetic resonance imaging (fMRI) scans.
BASELINE THROUGH FOLLOW-UP (4 WEEKS).
Opioid Craving
BASELINE TO ONE MONTH POST FOLLOW-UP (UP TO 2 MONTHS).
This outcome will be measured with the Opioid Craving Scale, a 3-item measure of craving that uses a 0-10 analog scale. Total possible score is 30, with higher score indicating more craving.
BASELINE TO ONE MONTH POST FOLLOW-UP (UP TO 2 MONTHS).
Opioid use
BASELINE TO ONE MONTH POST FOLLOW-UP.
Opioid use will be monitored by weekly urine test and the timeline followback method (TLFB). TLFB asks subjects to estimate drug use during a specific time period in the past.
BASELINE TO ONE MONTH POST FOLLOW-UP.
Negative affect
BASELINE TO ONE MONTH POST FOLLOW-UP (UP TO 2 MONTHS).
This outcome will be measured by the Quick Inventory of Depressive Symptomatology. This is a 16-item measure, using a 0-3 scale for each item. Total possible score is 48, with higher scores indicating greater symptom severity.
BASELINE TO ONE MONTH POST FOLLOW-UP (UP TO 2 MONTHS).

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes opioid abuse?

The causes of opioid abuse are many and varied. The fact that some are self-initiated and some are not, suggests that a range of factors are involved in determining their emergence. Prevention strategies cannot be targeting specific risk factors only. The fact that misuse is associated with poor health and well-being implies that it has major implications on society. The scope of this research underscores the need to find new research directions, or to use existing ones in more nuanced ways, to develop more tailored prevention strategies.

Anonymous Patient Answer

What are common treatments for opioid abuse?

There are three types of medications that can be prescribed for opioid abuse - naloxone, naltrexone and buprenorphine. These medications are helpful in preventing opioid overdoses in patients with a history of heroin and other opiate use. There are also different types of methadone maintenance treatment options, including naltrexone depot, as well as methadone rectal suppositories, which are often helpful in long-term treatment. There are a number of different long-term monitoring options, and the best option for each patient and situation depends on the specifics of treatment plans. There are also many treatment options for alcohol abuse that use different therapeutic methods, such as detoxification or abstinence.

Anonymous Patient Answer

What is opioid abuse?

The number of methadone recipients and heroin addicts have increased sharply since the late 1980s. The problem appears to be concentrated in areas most severely affected by the HIV epidemic rather than being widespread. It will be very difficult to control unless there is a concerted effort to educate communities and doctors about this health crisis.

Anonymous Patient Answer

How many people get opioid abuse a year in the United States?

The actual incidence of opioid abuse is likely higher than the prevalence data on the Internet. This higher figure would indicate a lack of awareness of current trends among physicians and public health officials in light of its implications for the treatment of patients diagnosed with an illicit drug prescription.

Anonymous Patient Answer

What are the signs of opioid abuse?

Among the most common signs of abuse include the use of naloxone (an antidote which stops opiate overdoses), and tolerance to the euphoric effects of prescription opioids (such as oxycodone and codeine). Chronic opioid users develop the hallmark sign of addiction, which is a psychological dependence.\n

Anonymous Patient Answer

Can opioid abuse be cured?

Treatment of opioid abuse can produce long-term and significant reductions in use and cravings. However, abstinence from opioids is difficult and, with many patients suffering residual cravings, only ~30% of them actually curtail opioid use. Current research, therefore, addresses various factors that may reduce the likelihood of relapse, and some that have been proven to help treat addiction in other forms of drug abuse. To optimize outcomes in opioid addicts, a multifaceted approach will be necessary.

Anonymous Patient Answer

Does opioid abuse run in families?

An attempt to map opioid abuse and dependence across families was limited by the absence of a familial component. However, familial opioid use was positively associated with an increased propensity to take opioids and a family history of drug use.

Anonymous Patient Answer

What is the primary cause of opioid abuse?

The majority of patients, 55-65% of all abusers and a majority, 66.7-75% of those who had had problems with opioids, report a mental health condition, and these mental disorders are more common in opioid abusers. However, mental disorders may be a consequence of opioid abuse. To combat the epidemic of opioid abuse, a multisliteral approach is needed that considers both the role of mental health conditions in the use of opioids and the need for new treatment options to combat mental illness.

Anonymous Patient Answer

Have there been other clinical trials involving experimental feedback?

In evaluating the best type of feedback, it has to be considered a combination of the type of feedback delivered, the feedback content, and the impact on the outcome of the trial.

Anonymous Patient Answer

How serious can opioid abuse be?

[Of patients with pain whose primary care physician prescribed pain medication (medication to be dispensed by a pharmacist or pharmacy), approximately 10% of patients continue to prescribe pain medication to their family members without pharmacists' or physicians' advice, a practice often referred to as 'prescribing' or 'overprescribing' (i.e.

Anonymous Patient Answer

How does experimental feedback work?

Although only one of the four key factors in the modified FTF model was significant, the model predicts outcomes of interventions that use feedback in their components but do not use feedback in the final evaluation. Although we do not know the true effect of feedbacks on outcomes, model-guided interventions using feedback components may provide useful information for practitioners.

Anonymous Patient Answer

What does experimental feedback usually treat?

Data from a recent study suggest that clinical feedback is an effective treatment for pain-related learning problems (specifically avoidance), but is a less effective treatment for the learning problems that are probably related to addiction. Therefore, future research aimed at applying these findings to clinical pain settings should focus on the learning problems that are probably related to addiction rather than on addiction itself.

Anonymous Patient Answer
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