Surgical resection and stereotactic body radiation therapy (SBRT) for Lung Cancer

Phase-Based Progress Estimates
McMaster University/St. Joseph's Hospital Healthcare, Hamilton, CanadaLung Cancer+3 MoreSurgical resection and stereotactic body radiation therapy (SBRT) - Procedure
All Sexes
What conditions do you have?

Study Summary

This trial is testing whether a particular type of radiation therapy can help to shrink tumors and improve outcomes for people with lung cancer.

Eligible Conditions
  • Lung Cancer
  • Surgical Resection
  • Pulmonary Metastasectomy
  • Stereotactic Body Radiotherapy

Treatment Effectiveness

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: post operative 3 years

Week 12
The effect on time-to-resection and tumour histology on pCR
Week 6
Identify mRNA tumor markers by Circulating Tumor Cell/CTC test
Year 3
Disease-free survival (DFS)
Post operative 3 years
Overall survival (OS)
Post radiation 1 year
Radiation related toxicity
post operative 3 years
local recurrence rates
post operative 30 days
Postoperative pulmonary complication rate (including prolonged air leak, need for invasive or noninvasive mechanical ventilation, postop pneumonia and empyema)
post-operative 3 weeks
Rates of complete pathologic response (pCR)

Trial Safety

Trial Design

1 Treatment Group

SBRT followed by pulmonary metastasectomy
1 of 1

Experimental Treatment

39 Total Participants · 1 Treatment Group

Primary Treatment: Surgical resection and stereotactic body radiation therapy (SBRT) · No Placebo Group · N/A

SBRT followed by pulmonary metastasectomy
Experimental Group · 1 Intervention: Surgical resection and stereotactic body radiation therapy (SBRT) · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: post operative 3 years

Who is running the clinical trial?

McMaster UniversityLead Sponsor
823 Previous Clinical Trials
1,732,393 Total Patients Enrolled
John Agzarian, MD, MPHPrincipal InvestigatorMcMaster University

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have cancer that has only spread to your lungs and not to any other organs, except for colorectal cancer that has spread to your liver at the same time.
You are over 18 years old and have cancer that has spread to your lungs, which can be completely removed with surgery. You have already received treatment for your primary cancer without any signs of it coming back. There are no other better treatment options available for you.

Frequently Asked Questions

Are recruitment efforts still underway for this research project?

"According to, this research is still looking for participants; the trial was initially posted on July 14th 2020 and has been amended most recently on February 23rd 2021." - Anonymous Online Contributor

Unverified Answer

How many participants are receiving treatment within this trial?

"Affirmative. confirms that this clinical study, which was launched on July 14th 2020, is still recruiting participants. Approximately 39 individuals need to be enrolled from a single site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.