qMRI Assessment After SBRT for Spinal Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine if quantitative magnetic resonance imaging (qMRI) can objectively measure changes in the tumor/vertebral body and adjacent spinal cord following stereotactic body radiation therapy (SBRT) for painful metastatic spine disease.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the treatment using qMRI and SBRT for spinal cancer safe for humans?
How is the treatment using Gadoteridol and qMRI after SBRT for spinal cancer different from other treatments?
This treatment is unique because it combines Gadoteridol, a contrast agent used in MRI scans, with quantitative MRI (qMRI) to assess the effectiveness of stereotactic body radiotherapy (SBRT) for spinal cancer. This approach may help in early detection of treatment response by providing detailed imaging biomarkers, which is not typically available with standard treatments.13567
Who Is on the Research Team?
Trey Mullikin, MD
Principal Investigator
Duke University
Are You a Good Fit for This Trial?
This trial is for adults with a pain score of at least 1/10 from spinal cancer metastases, who are expected to live more than 3 months and can undergo MRI scans. It's not for those with non-MRI compatible implants, severe claustrophobia, prior vertebral interventions causing artifacts (except some surgeries), pregnant or breastfeeding women, people allergic to MRI contrast agents, or those with very poor kidney function.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive stereotactic body radiation therapy (SBRT) for spinal metastases
Imaging Assessment
Quantitative MRI is performed to assess changes in the tumor/vertebral body and adjacent spinal cord
Follow-up
Participants are monitored for safety and effectiveness after radiation therapy
What Are the Treatments Tested in This Trial?
Interventions
- Gadoteridol
- qMRI
Gadoteridol is already approved in European Union, United States for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Duke University
Lead Sponsor