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Olaparib + Radiotherapy for Small Cell Lung Cancer
Study Summary
This trial is testing the safety of a new drug, Olaparib, given with radiation therapy to people with small cell lung cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 3 trial • 854 Patients • NCT00003389Trial Design
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Who is running the clinical trial?
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- I have had treatment for spinal cord compression and have been stable for 28 days.My lung disease can be targeted with radiation according to my doctor.I have brain metastases that have not been treated.My blood tests, liver, and kidney functions are within normal ranges.I am postmenopausal or cannot become pregnant.I am willing and able to follow the study's requirements, including treatments and check-ups.I have recovered from side effects of my previous cancer treatment.I have inflammation in my lungs.My heart's electrical activity is irregular, or I have a family history of long QT syndrome.I stopped my immunotherapy 10 days before starting and will wait 10 days after this treatment.I have lasting side effects from cancer treatment, but not hair loss.I do not have any serious, uncontrolled health issues or active infections.Women who are currently breastfeeding.You are allergic to olaparib or any of the ingredients in the medication.I have not had a blood transfusion in the last 4 months.My cancer has spread within my lung and to the surrounding fluid.I completed 4-6 cycles of specific chemotherapy within the last 8 weeks.My cancer did not worsen after finishing chemotherapy.I am 18 years old or older.I haven't had chemotherapy or chest radiation in the last 3 weeks.I am fully active or have some restrictions but can take care of myself.I haven't taken any experimental drugs within the last 30 days or 5 half-lives.I am not taking strong or moderate CYP3A inhibitors.I have been diagnosed with myelodysplastic syndrome or acute leukemia.I cannot swallow pills or have stomach issues affecting medication absorption.I have had a bone marrow or double cord blood transplant.I do not have symptoms from brain metastases.I have been treated with a PARP inhibitor for small cell lung cancer.Patients with weakened immune systems.I agree to use two effective birth control methods during and for 3 months after treatment.I am not undergoing or have chosen not to undergo chest radiation therapy.I have active hepatitis.I have had radiation therapy to the chest area before, but not for breast cancer.I have not had major surgery in the last 2 weeks or have fully recovered from one.My small cell lung cancer diagnosis was confirmed by a specialist.I haven't had any other cancer in the last 5 years.
- Group 1: Participants with Small Cell Lung Cancer
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What medical conditions are ameliorated by treatments involving radiotherapy?
"Radiotherapy is a viable form of treatment for advance directives, malignant neoplasms of the ovary, and primary peritoneal cancer."
Is the research team currently enlisting participants for this experiment?
"This particular trial has ceased its recruitment efforts. Initially posted on 12th of July 2018, the study was last updated in September 2022. If you are seeking other trials to join, there are 1573 clinical studies actively enrolling patients with small cell lung carcinoma and 188 Radiotherapy related attempts which require volunteers."
What is the current intake of individuals for this experiment?
"This clinical trial, posted on July 12th 2018 and last updated September 14th 2022, is no longer recruiting patients. If you are interested in similar investigations, there are 1,573 trials for small cell lung carcinoma that are currently enrolling participants as well as 188 radiotherapy studies actively recruiting."
How many locations globally are partaking in this research?
"Nine medical centres are currently taking part in this trial, including Memorial Sloan Kettering Westchester located in Harrison and its two sister sites - the New york City-based Memorial Sloan Kettering Cancer Center and Commack's Memorial Sloan Kettering Commack. Additionally, 6 other treatment locations have also been recruited to take part."
Has the FDA approved Radiotherapy as a viable remedy?
"Due to the initial stage of research, safety ratings for Radiotherapy were assigned a score of 1. This indicates that there is minimal data available attesting to its efficacy and security."
Has there ever been a similar trial conducted before this one?
"Presently, 188 clinical trials concerning Radiotherapy are in progress across 1469 cities and 60 nations. The first study of its kind was performed by AstraZeneca in 2005 with the participation of 98 individuals; it concluded Phase 1 drug approval. Since then 205 further studies have been administered."
Are there prior experiments that have employed Radiotherapy as a treatment?
"Presently, there are 188 ongoing studies that investigate the effectiveness of radiotherapy. 27 of these live trials have progressed to Phase 3. Most sites conducting this research can be found in Houston, Texas though a grand total 9255 locations are running clinical tests for Radiotherapy."
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