Michael D. Offin, MD - MSK Thoracic ...

Dr. Michael Offin

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Memorial Sloan Kettering Cancer Center

Studies Mesothelioma
Studies Lung Cancer
5 reported clinical trials
12 drugs studied

Area of expertise

1Mesothelioma
Michael Offin has run 3 trials for Mesothelioma. Some of their research focus areas include:
systemic
unresectable
2Lung Cancer
Michael Offin has run 3 trials for Lung Cancer. Some of their research focus areas include:
Stage IV
BRAF positive
NRAS positive

Affiliated Hospitals

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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Westchester

Clinical Trials Michael Offin is currently running

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Sacituzumab Govitecan

for Mesothelioma

Participants will receive sacituzumab govitecan until their disease gets worse (progresses), they have severe side effects and cannot continue study treatment, or the participants or the study doctor thinks it's in your best interest to stop treatment.
Recruiting1 award Phase 24 criteria
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BDTX-4933

for Cancer

BDTX-4933-101 is a first-in-human, open-label, Phase 1/2 dose escalation, dose optimization and expansion study designed to evaluate the safety and tolerability of S241656 as monotherapy and in combination with other anti-cancer therapies in participants with selected advanced malignancies. The study population for the Dose Escalation part of the study comprises adults with recurrent advanced/metastatic non-small cell lung cancer (NSCLC), Gastrointestinal (GI) cancers, and other solid tumors harboring KRAS, HRAS, NRAS, BRAF, and/or CRAF (Rapidly Accelerated Fibrosarcoma (RAF1)) mutations or alterations. A dose optimization part in adults with NSCLC may follow the dose escalation phase if the sponsor, in consultation with the safety review committee, decides it is necessary to further characterize the optimal dose. However, the study may also proceed directly to the expansion phase. The study population for the Dose Expansion part of the study comprises adults with advanced/metastatic NSCLC with KRAS and/or BRAF mutations, and with Pancreatic Ductal AdenoCarcinoma (PDAC), ColoRectal Cancer (CRC), and Biliary Tract Cancer (BTC) with KRAS, HRAS, NRAS, BRAF, and/or CRAF (RAF1) mutations and alterations. All patients will self-administer S241656 orally in 28-day cycles until disease progression, toxicity, withdrawal of consent, or termination of the study.
Recruiting1 award Phase 1 & 2

More about Michael Offin

Clinical Trial Related8 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Michael Offin has experience with
  • Sacituzumab Govitecan
  • Cisplatin Or Carboplatin
  • Nivolumab
  • Pemetrexed
  • Surgery
  • LTT462

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