Treatment for Depression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Manitoba - College of Medicine, Winnipeg, Canada
Depression+4 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a web-based program can help people with inflammatory bowel disease cope with stress, anxiety or depression.

See full description

Eligible Conditions

  • Depression
  • Anxiety
  • Inflammatory Bowel Diseases (IBD)

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes and 4 secondary outcomes in patients with Depression. Measurement will happen over the course of Baseline, 6 weeks, 12 weeks, 24 weeks.

Week 24
Change in Clinical Global Impression - Improvement scale (CGI-I)
Change in Hospital Anxiety and Depression Scale (HADS)
Change in Inflammatory Bowel Disease Symptom Inventory - Short Form (IBDSI)
Change in Patient-Reported Outcomes Measurement Information System - 29 (PROMIS-29)
Change in Perceived Stress Scale 4 (PSS-4)
Change in the Work and Social Adjustment Scale (WSAS)

Trial Safety

Safety Estimate

1 of 3

Trial Design

0 Treatment Group

This trial requires 50 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 6 weeks, 12 weeks, 24 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 6 weeks, 12 weeks, 24 weeks for reporting.

Closest Location

University of Manitoba - College of Medicine - Winnipeg, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Depression or one of the other 4 conditions listed above. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
- in his early twenties, Canadian Brian Kuruvilla refused to let the chronic, often disabling disease control his life show original
A score on a scale measuring stress, anxiety or depression indicating the presence of a problem that requires treatment. show original
Having a personal computer with regular access to the internet would allow you to have access to this program. show original
is a prerequisite for the job You must be able to read and write English in order to qualify for this job. show original

Patient Q&A Section

How many people get inflammatory bowel diseases a year in the United States?

"The prevalence of IBD among all Americans is estimated to number 12 million, or about 1% of people. The prevalence of IBD among whites is estimated to be about half of that among Native Americans, and among African Americans, but not among Asian Americans. As a result, there are no projected changes in the overall prevalence of IBD in the US over the next decade. The most important risk factor for IBD is advancing age, followed by the presence of first-degree relatives with IBD." - Anonymous Online Contributor

Unverified Answer

What is inflammatory bowel diseases?

"Symptoms and signs of intestinal inflammatory autoimmune conditions present with high frequency during clinical encounters. The majority of IBD patients were diagnosed in an adult setting. The disease is more often seen in women from the African-American and Hispanic populations." - Anonymous Online Contributor

Unverified Answer

Can inflammatory bowel diseases be cured?

"The literature available on the management of IBD seems to suggest a 'wait and see' approach to management where all treatment modalities are available. Patients and their partners have a critical role in the assessment of disease activity and symptom severity, and this information should dictate appropriate therapy." - Anonymous Online Contributor

Unverified Answer

What causes inflammatory bowel diseases?

"At a fundamental level the development of IBD depends on the interplay of many genes and environmental factors and, by definition, is a chronic disorder." - Anonymous Online Contributor

Unverified Answer

What are the signs of inflammatory bowel diseases?

"Symptoms consistent with inflammation such as: anemia, fatigue, abdominal discomfort, diarrhea and an abnormally high white cell count or erythrocyte sedimentation rate are common in patients with inflammatory bowel disease, as is a low serum albumin. Although patients with IBD have similar symptoms to the majority of patients with inflammatory bowel disease, symptoms are often not of a serious nature, and are easily dismissed. A more specific definition of signs and symptoms specific to IBD is required to identify patients more readily with this condition." - Anonymous Online Contributor

Unverified Answer

What are common treatments for inflammatory bowel diseases?

"There are a few classes of medications that have shown efficacy in treating ulcerative colitis and Crohn disease. These include 5-ASA and immunomodulators, such as infliximab. There are also two medications that have been approved by the FDA for the treatment of Crohn disease: certolizumab (Cimzia), a anti IL-12 drug, and ustekinumab (Strensiq), a therapeutic anti IL-23 antibody. There are also many medications used as adjuvant therapy to 5-ASA and immunomodulators, such as mesalamine. Also, there are a few new classes of medications, such as those that target TNF." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Physicians often prescribe medications in combinations with other treatments to achieve the best patient outcomes. Physicians also often use medication combinations together to treat the coexistence of their diseases. These medications are generally well tolerated and often have good safety profiles. Physicians often use these combinations to treat the complex clinical problems and to prevent the onset of acute clinical conditions." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of inflammatory bowel diseases?

"While Crohn's disease is known to affect males and females alike, Ulcerative Colitis occurs more frequently in females than males. For non-neurological indications, patients diagnosed with Irritable Bowel Syndrome (IBS) will receive antispasmodic drugs, while patients diagnosed with IBD-without any neurological or gastrointestinal symptoms should be monitored and treated with antispasmodic medications if necessary. Also, an IBD diet is a key aspect to treating patients with IBD." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"The efficacy of the treatment does not depend on the extent of inflammation or tissue reaction. Treatment with glucocorticoids and immunosuppressants does not inhibit infiltration. Rather, treatment with glucocorticoids suppresses the inflammatory reaction. The efficacy of glucocorticoid therapy does not depend on the tissue damage." - Anonymous Online Contributor

Unverified Answer

Does treatment improve quality of life for those with inflammatory bowel diseases?

"Patients with IBD who had previously been on conventional medical treatment were seen to use greater health care resources for IBD treatment than those receiving self-management or IBD education only. Treatment did not appear to improve QOL compared with self-management and IBD education only. There was a difference in the percentage of patients who used health care resources." - Anonymous Online Contributor

Unverified Answer

Has treatment proven to be more effective than a placebo?

"For inpatient Crohn's disease, we do not have reliable data on treatment efficacy. In a randomized controlled trial a treatment effect was proven from our meta-analysis." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets inflammatory bowel diseases?

"IBD is a rare disease, with an prevalence of 2.5 per 100,000 person-years in Norway; it affects 0.5 percent of males and 3 percent of females before the age of 45. Before the age of 40, prevalence was higher. Older patients were more likely to have pouchitis than younger patients." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Depression by sharing your contact details with the study coordinator.