This trial is evaluating whether Autologous EPCs transfected with human eNOS will improve 6 secondary outcomes in patients with Hypertension, Pulmonary. Measurement will happen over the course of 12 months.
This trial requires 45 total participants across 3 different treatment groups
This trial involves 3 different treatments. Autologous EPCs Transfected With Human ENOS is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 & 3 and have had some early promising results.
"In China, patients with hypertension have a lower risk of death from cardiovascular disease than the general population when treated to the treatment guideline. Thus, the treatment for hypertension in China is beneficial. More rigorous and extensive clinical studies are needed to support the treatment guidelines." - Anonymous Online Contributor
"The signs of pulmonary hypertension include:\n\n1. shortness of breath\n\n2. a raised jugular pressure\n\n3. blue sclera in the periphery\n\n4. ascites, and a loud heart, diastolic and systolic murmurs that are best heard with a stethoscope.\n\n5. a blue tinge to the lips\n\n6. blue skin\n\n7. a muffled heart sound\n\n8. a systolic murmur\n\n9. diastolic murmur\n\n10. palpitations\n\n11." - Anonymous Online Contributor
"Hypertension, pulmonary is the third leading cause of death in the United States. It is usually a result of heart disease. Hypertension, pulmonary affects many parts of the body, the heart being the first part of the system to show effects. In order for an individual to be affected, hypertension, pulmonary will need to be a part of their overall health and fitness. If an individual who has experienced this illness prior has the chance to prevent it from ever taking their lives, it is important to understand the symptoms, causes, and treatments as well as how to recognize if the individual has the disease." - Anonymous Online Contributor
"The prevalence of hypertension is similar in men and women; however, it is more prevalent in smokers. Hypertension often occurs together with hypertension in elderly people. In children, high blood pressure and low physical activity are risk factors for hypertension. In particular, smoking and alcohol consumption have an adverse effect on hypertension, whereas in older adults smoking and drinking decrease blood pressure and this is associated with a reduced risk of death." - Anonymous Online Contributor
"The presence of a secondary diagnosis is a contraindication to use of ACE inhibitors for treatment of hypertension. If there is no contraindication to ACE inhibitor use, they remain an effective and safe option for treatment of hypertension." - Anonymous Online Contributor
"A year ago, nearly 2.5 million Americans were new cases of hypertension, and 862,000 new cases of pulmonary hypertension were recorded. This is a 5% increase in new hypertension cases and a 15% increase in new pulmonary hypertension cases compared with 1998." - Anonymous Online Contributor
"autologous epidCS transfection can produce effective and safe immunization in alloxan-induced diabetic rats. autologous epidCS transfection can also produce effective vaccine and effective immunization in allergenic rats, but the immunizing efficacy of this vaccine is poor in both models." - Anonymous Online Contributor
"Primary hypertension, especially in older persons (60 years or more), is mainly caused by increased resistance in the pulmonary circulation and increased capillary pressure. It is characterized by high pulmonary vascular resistance and low capillary blood flow. Most cases are attributable to the chronic high levels of blood pressure that develop slowly over time in hypertensive persons." - Anonymous Online Contributor
"Hypertension is the single greatest risk factor for death and disability among people with chronic disease. While hypertension is a great obstacle to many people with chronic disease, the majority lack a well-equipped treatment unit. Physicians have a responsibility and an opportunity to advance the treatment and management of chronic disease. Our literature review shows an improvement in the quality of the research and the advancements in the understanding of chronic disease. We expect the greatest improvements in the management of chronic disease to be in the future." - Anonymous Online Contributor
"Almost 8 in 10 persons with hypertension, pulmonary got their first diagnosis after the age of 50, particularly in men. As these data reflect an emerging cohort of patients with hypertension, prevention campaigns should address individuals with greater than average age at diagnosis." - Anonymous Online Contributor
"Autologous EPCS transfected with human rEN gene improves quality of life for patients with hypertension or pulmonary hypertension, possibly by suppressing proinflammatory pathways. EPCS-derived protein could be an effective target for therapy of these chronic diseases." - Anonymous Online Contributor