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Progestin

Desogestrel for Congenital Central Hypoventilation Syndrome

Phase 2

Waitlist Available

Led By Iris Perez, MD

Research Sponsored by Children's Hospital Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 hours

Awards & highlights

Study Summary

This trial is testing whether or not taking a progesterone-containing oral contraceptive can improve CO2 and oxygen responsivity, as well as spontaneous ventilation during sleep, in females with CCHS who are >15-years of age.

Eligible Conditions

Congenital Central Hypoventilation Syndrome

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hypercapnic Ventilatory Response

Hypoxic Ventilatory Response

Time Maintained Ventilation Off Mechanical Ventilation During Sleep.

Secondary outcome measures

Time That the Patient Maintains Adequate Ventilation

Trial Design

1Treatment groups

Experimental Treatment

Group I: Females with CCHS > 16 years old on desogestrelExperimental Treatment1 Intervention

open label studied on drug.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Desogestrel

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Children's Hospital Los AngelesLead Sponsor

232 Previous Clinical Trials

5,076,767 Total Patients Enrolled

1 Trials studying Congenital Central Hypoventilation Syndrome

500 Patients Enrolled for Congenital Central Hypoventilation Syndrome

Iris Perez, MDPrincipal InvestigatorChildren's Hospital Los Angeles

Media Library

Desogestrel (Progestin) Clinical Trial Eligibility Overview. Trial Name: NCT01500473 — Phase 2

Congenital Central Hypoventilation Syndrome Research Study Groups: Females with CCHS > 16 years old on desogestrel

Congenital Central Hypoventilation Syndrome Clinical Trial 2023: Desogestrel Highlights & Side Effects. Trial Name: NCT01500473 — Phase 2

Desogestrel (Progestin) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01500473 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scope of enrollment for this experiment?

"Unfortunately, recruitment for this trial is no longer available as the posting was most recently updated on February 13th of 2012. If you are looking to join other similar studies, there are 1408 trials recruiting patients with syndrome and 5 clinical trials that accept desogestrel candidates."

Answered by AI

May I partake in this clinical trial?

"This medical trial seeks to recruit approximately 8 persons who suffer from a specified syndrome and are aged between 16 and 50."

Answered by AI

Is the current research protocol open to senior participants?

"This medical trial only accepts patients between the ages of 16 and 50. Conversely, there are 380 trials for those below 16 years old and 1003 for senior citizens above 65."

Answered by AI

Are there any open slots currently available to join the trial?

"The clinicaltrials.gov website reveals that this medical trial is no longer in the process of patient recruitment, as it was initially posted on February 1st 2012 and last modified on February 13th 2012. However, 1413 other trials are still actively searching for participants at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome

Iris Perez 2012. "Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01500473.