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11C-Martinostat for Heart Failure

N/A

Waitlist Available

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 10-60 minutes post-injection

Awards & highlights

Study Summary

This trial is testing a new radioligand that could help improve diagnosis and treatment of aortic stenosis and diabetes.

Eligible Conditions

Heart Failure With Preserved Ejection Fraction
Aortic Valve Stenosis
Left Ventricular Hypertrophy
Diabetes

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 10-60 minutes post-injection

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~10-60 minutes post-injection

This trial's timeline: 3 weeks for screening, Varies for treatment, and 10-60 minutes post-injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

11C-Martinostat Binding

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Aortic Stenosis Patient SubjectsExperimental Treatment2 Interventions

Patient subjects with aortic stenosis will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI before and after transcatheter valve replacement.

Group II: Diabetes Patient SubjectsActive Control2 Interventions

Patient subjects with diabetes will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI.

Group III: Healthy SubjectsActive Control2 Interventions

Healthy subjects will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

PET-MRI

2018

N/A

~100

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Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,933 Previous Clinical Trials

13,198,385 Total Patients Enrolled

49 Trials studying Heart Failure

209,625 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the requirements for potential participants in this experiment?

"To be admitted into this medical experiment, individuals must have aortic valve stenosis and fall within the age range of 18-85. At present, 96 patients are being recruited for participation."

Answered by AI

Does this research protocol include adults of all ages?

"This trial is open for patients aged 18 to 85. For those younger than 18, there are 56 studies available and 375 research opportunities for seniors 65 or older."

Answered by AI

What is the aggregate amount of individuals enrolled in this clinical experiment?

"Indeed, the information from clinicaltrials.gov implies that this medical experiment is currently in recruitment mode. The study was originally uploaded on September 7th 2018 and was recently revised on March 1st 2022. 96 participants need to be enrolled at one particular healthcare facility."

Answered by AI

Has 11C-Martinostat been studied in other research projects?

"Currently, there is only one ongoing trial involving 11C-Martinostat and it has not yet reached Phase 3. The research site for this medication is located in Boston, Massachusetts."

Answered by AI

Is this experiment currently accepting participants?

"Affirmative, clinicaltrials.gov's records indicate that this trial is still recruiting patients. It was first uploaded on September 7th 2018 and the most recent update was released March 1st 2022; 96 participants are needed from a single medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Imaging Histone Deacetylase in the Heart

David E Sosnovik 2018. "Imaging Histone Deacetylase in the Heart". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03549559.