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Immunotherapy

Egg allergy oral desensitization for Egg Allergy

N/A

Waitlist Available

Research Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 18 months

Awards & highlights

Study Summary

This trial is testing whether people with egg allergies can be taught to tolerate them by slowly exposing them to increasing amounts of egg.

Eligible Conditions

Egg Allergy

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 18 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~18 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Efficacy of desensitization in egg allergic patients as assessed by presence or absence of allergic symptoms during a blinded, placebo controlled oral food challenge

Secondary outcome measures

Change from baseline over the immunotherapy process of Regulatory T cell levels

Change from baseline over the immunotherapy process of egg specigic IgA levels

Change from baseline over the immunotherapy process of egg specigic IgE levels

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: TreatmentExperimental Treatment1 Intervention

Following randomization, participants in this group will receive escalating doses of egg protein, up to a dose of 300 mg. Once they attain that dose, they will maintain it for six months. At the end of this maintenance period, they will undergo a singe-blind, placebo-controlled oral food challenge

Group II: ControlActive Control1 Intervention

Following randomization, this arm will receive no intervention. After twelve months, participants in this group will undergo a singe-blind, placebo-controlled oral food challenge

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Who is running the clinical trial?

McGill University Health Centre/Research Institute of the McGill University Health CentreLead Sponsor

444 Previous Clinical Trials

159,498 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially meet the criteria for taking part in this research?

"This trial is recruiting 50 participants, aged 6 to 20 and with existing egg proteins. To qualify for the study they need to fulfil these conditions: Children age 6 or greater; parental/guardian consent (appendix B); anamnestic data of IgE-mediated reaction within 120 minutes of ingestion, inhalation or contact (mild symptoms include pruritus, urticaria etc., moderate involve angioedema et al., severe including wheeze, cyanosis and circulatory collapse); positive oral challenge test through Meringue Powder per EAACI's position paper & done in open manner (Appendix C); positive"

Answered by AI

Is this research endeavor still accepting participants?

"This research initiative, which was initially listed on July 3rd 2018, is not accepting new patients at this time. Nevertheless, there are 257 other clinical trials presently enrolling participants."

Answered by AI

Is this medical investigation enrolling individuals under the age of 35?

"Patients aged 6 to 20 qualify for this medical experiment, while there are 82 separate trials available for minors and 157 studies suitable for elderly participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Egg Allergy Oral Desensitization

Bruce Mazer 2018. "Egg Allergy Oral Desensitization". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04027465.

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