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Contingency Management (CM) for Human Immunodeficiency Virus Infection (PRISM Trial)

N/A

Waitlist Available

Led By Adam W Carrico, PhD

Research Sponsored by Florida International University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

PRISM Trial Summary

This trial is testing whether a combination of two methods, contingency management and motivational interviewing, can help stimulant-using men who have sex with men enter into and continue PrEP care.

Eligible Conditions

Human Immunodeficiency Virus Infection
Pre-Exposure Prophylaxis
Substance Use Disorder

PRISM Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Filling a prescription for PrEP

Secondary outcome measures

Self-reported PrEP clinical evaluation by a medical provider

Self-reported condomless insertive anal sex (Insertive CAS)

Self-reported condomless receptive anal sex (Receptive CAS)

+1 more

Side effects data

From 2021 Phase 2 trial • 118 Patients • NCT02896712

10%

Drowsiness

10%

Weakness

10%

Muscle Aches

10%

Blurry Vision

10%

Fatigue

Symptoms of Congestive Heart Failure

Skin Rash

Difficulty Walking

Asthma Attack

Upper Respiratory Infection

Vomiting

Increased Urination

100%

80%

60%

40%

20%

Study treatment Arm

Phase 2: DC Plus CM, With Modafinil

Phase 2: ACT Plus CM, With Modafinil

Phase 2: DC Plus CM Only

Phase 2: DC Plus CM, With Placebo

Phase 1: Acceptance and Commitment Therapy (ACT) Plus Contingency Management (CM) Only

Phase 1: Drug Counseling (DC) Plus Contingency Management (CM) Only

Phase 2: ACT Plus CM Only

Phase 2: ACT Plus CM, With Placebo

PRISM Trial Design

4Treatment groups

Experimental Treatment

Group I: Motivational Interviewing (MI) - OnlyExperimental Treatment1 Intervention

Two MI sessions focusing on stimulant use, sexual risk, and PrEP use will be delivered.

Group II: MI+CMExperimental Treatment2 Interventions

Two MI sessions focusing on stimulant use, sexual risk, and PrEP use will be delivered. Participants who do not fill a PrEP prescription at 3 months will receive CM financial incentives for PrEP clinical evaluation and filling a PrEP prescription.

Group III: Contingency Management (CM) - OnlyExperimental Treatment1 Intervention

CM will include financial incentives for PrEP clinical evaluation and filling a PrEP prescription.

Group IV: CM+MIExperimental Treatment2 Interventions

CM will include financial incentives for PrEP clinical evaluation and filling a PrEP prescription. Participants who do not fill a PrEP prescription at 3 months will then receive 2 sessions of MI.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Motivational Interviewing (MI)

2010

Completed Phase 3

~2830

Contingency Management (CM)

2016

Completed Phase 2

~420

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Florida International UniversityLead Sponsor

100 Previous Clinical Trials

17,485 Total Patients Enrolled

City University of New YorkOTHER

17 Previous Clinical Trials

5,583 Total Patients Enrolled

National Institute on Drug Abuse (NIDA)NIH

2,468 Previous Clinical Trials

2,619,279 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scale of enrollment for this research project?

"Affirmative. Clinicaltrials.gov confirms that this study, first posted on October 16th 2020, is actively seeking participants for enrollment. A total of 70 people need to be recruited from 1 clinical site."

Answered by AI

Are there any vacancies available to participants in this research program?

"As obvious from clinicaltrials.gov, this trial is presently trying to find eligible applicants. It was originally published on October 16th 2020 and the most recent iteration of it occurred on October 13th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

PrEP Readiness Interventions for Supporting Motivation

Adam Carrico, PhD 2020. "PrEP Readiness Interventions for Supporting Motivation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04205487.