PS-OCT Eye Scan for Retinal Imaging
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new eye scan method, called polarization-sensitive optical coherence tomography (PS-OCT), to evaluate its ability to capture detailed images of the retina, the light-sensitive layer at the back of the eye. The focus is on obtaining high-quality views of a specific part of the retina in healthy eyes. Only individuals with healthy eyes, free of major eye diseases (except for mild cataracts), and who meet certain vision criteria qualify for this trial.
As an unphased study, this trial allows participants to contribute to groundbreaking research in eye imaging technology.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this imaging technique is safe for retinal imaging?
Research has shown that Polarization-Sensitive Optical Coherence Tomography (PS-OCT) is generally safe for people. Studies have found that PS-OCT can create clear images of the eye's nerve layers, aiding doctors in assessing the thickness and patterns in the retina, the light-sensing part of the eye.
The studies do not mention any harmful side effects. As a non-invasive technique, it does not involve surgery or entering the body, often enhancing its safety. In past research, this method was used successfully on healthy eyes without any reported problems, suggesting that PS-OCT is well-tolerated and safe for examining the retina.12345Why are researchers excited about this trial?
Researchers are excited about the PS-OCT Eye Scan because it offers a new way to image the retina using Polarization-Sensitive Optical Coherence Tomography (PS-OCT). Unlike traditional imaging methods, PS-OCT provides detailed insights into the nerve fiber layer of the retina, which could lead to earlier detection and better understanding of retinal health. This advanced imaging technique works by using light waves to create highly detailed, cross-sectional images, offering a non-invasive and potentially more accurate option for retinal assessment.
What evidence suggests that this PS-OCT eye scan is effective for retinal imaging?
Research has shown that polarization-sensitive optical coherence tomography (PS-OCT) holds promise for eye health. In this trial, PS-OCT will examine the nerve fiber layer (NFL) in the healthy retina. PS-OCT detects changes in light as it passes through different parts of the retina, the light-sensitive layer at the back of the eye. This capability helps doctors assess the health of the nerve fiber layer, crucial for good vision. Studies have found that PS-OCT can detect damage in this layer, essential for diagnosing eye diseases like glaucoma. The technology also enhances image clarity by reducing background noise and revealing more detail. Overall, PS-OCT offers a clearer view of retinal health.13678
Who Is on the Research Team?
Benjamin Vakoc, Ph.D.
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
This trial is for men and women aged 18-85 who are generally healthy with no significant eye diseases, except mild cataracts. Participants should have a clear cornea or media allowing for imaging and a refractive error within -5.00 to +5.00 spherical units.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Polarization Sensitive Optical Coherence Tomography (PS-OCT) Imaging will be used to look at the nerve fiber layer (NFL) in the healthy retina
Follow-up
Participants are monitored for safety and effectiveness after imaging
What Are the Treatments Tested in This Trial?
Interventions
- Polarization-Sensitive OFDI
Trial Overview
The study is testing the effectiveness of a new retinal imaging system called Polarization-Sensitive Optical Coherence Tomography (PS-OCT). It aims to capture high-quality images of the retina's birefringence in healthy subjects.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Polarization Sensitive Optical Coherence Tomography (PS-OCT) Imaging will be used to look at the nerve fiber layer (NFL) in the healthy retina.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
Massachusetts Eye and Ear Infirmary
Collaborator
Citations
Retinal imaging with polarization-sensitive optical coherence ...
Polarization-sensitive OCT (PS-OCT) enables simultaneous intensity and depth-resolved measurements of the polarization state in turbid media [8–12].
Polarization Sensitive Optical Coherence Tomography (PS ...
Polarization Sensitive Optical Coherence Tomography (PS-OCT) Imaging will be used to look at the nerve fiber layer (NFL) in the healthy retina. Intervention/ ...
Fiber-based polarization-sensitive OCT of the human retina ...
The correction of system polarization distortions yielded reduced phase retardation noise, and better estimates of the diattenuation and the relative optic axis ...
Retinal Nerve Fiber Layer Damage Assessment in ...
Retinal nerve fiber layer damage assessment in glaucomatous eyes using retinal retardance measured by polarization-sensitive optical coherence tomography.
Synthetic polarization-sensitive optical coherence ...
We developed a deep-learning method to synthesize PS-OCT images by training a generative adversarial network (GAN) on OCT intensity and PS-OCT images.
Retinal nerve fiber bundle tracing and analysis in human eye ...
We present a new semi-automatic processing method for retinal nerve fiber bundle tracing based on polarization sensitive optical coherence tomography ...
Visualization of phase retardation of deep posterior eye by ...
Polarization-sensitive optical coherence tomography (PS-OCT) can measure cross-sectional and volumetric images of birefringence in fibrous tissues that ...
Thickness and Birefringence of Healthy Retinal Nerve Fiber ...
Polarization-sensitive optical coherence tomography (PS-OCT) can provide objective information on RNFL thickness and birefringence.
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