MR Elastography for Intracranial Hypertension
Trial Summary
What is the purpose of this trial?
Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Lumbar puncture, Spinal tap, LP, MR elastography, Magnetic Resonance Elastography, MR Elastography, MRE, MRI structural brain imaging, Magnetic Resonance Imaging, MRI, Optical Coherence Tomography (OCT) imaging, Optical Coherence Tomography imaging, OCT imaging, Optic nerve B-scan ultrasound, Optic nerve B-scan ultrasound, B-scan ultrasound of the optic nerve for Intracranial Hypertension?
Research shows that Magnetic Resonance Elastography (MRE) can accurately measure brain stiffness, which is useful in conditions like elevated intracranial pressure. In a study, MRE was used to assess brain stiffness in patients with pseudotumor cerebri (a condition similar to intracranial hypertension) before and after lumbar puncture, showing its potential to provide valuable clinical information.12345
Is MR Elastography safe for use in humans?
How is the treatment of MR Elastography for Intracranial Hypertension different from other treatments?
MR Elastography (MRE) is unique because it noninvasively measures brain stiffness by analyzing how shear waves move through brain tissue, which can help assess changes in brain pressure before and after a lumbar puncture (spinal tap). This approach is different from other treatments as it provides detailed mechanical insights into brain tissue without the need for invasive procedures.12378
Research Team
John J Chen, M.D., Ph.D.
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for adults with conditions like idiopathic intracranial hypertension or obstructive hydrocephalus, which cause increased pressure inside the skull. It's also for those without such pressure issues to serve as a comparison group. People can't join if they're under 18, pregnant, or have conditions that make MR imaging unsafe for them.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo MR elastography, MRI, OCT imaging, and optic nerve B-scan ultrasound to establish baseline measurements
Intervention
Participants may receive interventions such as lumbar punctures, medications, or surgical interventions to lower intracranial pressure
Follow-up
Participants are monitored for changes in brain stiffness and other measurements after interventions
Treatment Details
Interventions
- Lumbar puncture
- MR elastography
- MRI structural brain imaging
- Optical Coherence Tomography (OCT) imaging
- Optic nerve B-scan ultrasound
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Eye Institute (NEI)
Collaborator