Study Summary
This trial looks for biomarkers that could help predict how someone will respond to weight loss, in terms of their metabolism.
Eligible Conditions
- Weight Loss
- Obesity
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 7 Secondary · Reporting Duration: 18 months
18 months
change in 24h urine catecholamines during and after weight loss
change in circulating AgRP during and after weight loss
change in circulating GLP-1 during and after weight loss
change in circulating PYY during and after weight loss
change in circulating leptin during and after weight loss
change in circulating thyroid hormones during and after weight loss
change in heart rate variability during and after weight loss
change in measured and predicted resting metabolic rate during and after weight loss
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
lifestyle intervention
1 of 2
lifestyle intervention plus phentermine-topiramate
1 of 2
Experimental Treatment
60 Total Participants · 2 Treatment Groups
Primary Treatment: lifestyle intervention with meal replacement program · No Placebo Group · N/A
lifestyle intervention
Other
Experimental Group · 1 Intervention: lifestyle intervention with meal replacement program · Intervention Types: Otherlifestyle intervention plus phentermine-topiramate
Other
Experimental Group · 1 Intervention: phentermine-topiramate combined with lifestyle intervention · Intervention Types: OtherTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 18 months
Who is running the clinical trial?
Medical College of WisconsinLead Sponsor
566 Previous Clinical Trials
1,154,058 Total Patients Enrolled
3 Trials studying Weight Loss
280 Patients Enrolled for Weight Loss
Lisa L Morselli, MD PhDPrincipal InvestigatorMedical College of Wisconsin
Eligibility Criteria
Age 18 - 50 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Georgia | 33.3% |
| Florida | 33.3% |
| Wisconsin | 33.3% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Medical College of Wisconsin | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
How responsive is this trial?
Typically responds via
| 100.0% | |
Most responsive sites:
- Medical College of Wisconsin: < 48 hours
Average response time
- < 2 Days
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Conditions
Cancer Related
Treatments