lifestyle intervention with meal replacement program for Weight Loss

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Weight Loss+1 Morelifestyle intervention with meal replacement program - Other
Eligibility
18 - 50
All Sexes
What conditions do you have?
Select

Study Summary

This trial looks for biomarkers that could help predict how someone will respond to weight loss, in terms of their metabolism.

Eligible Conditions
  • Weight Loss
  • Obesity

Treatment Effectiveness

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: 18 months

18 months
change in 24h urine catecholamines during and after weight loss
change in circulating AgRP during and after weight loss
change in circulating GLP-1 during and after weight loss
change in circulating PYY during and after weight loss
change in circulating leptin during and after weight loss
change in circulating thyroid hormones during and after weight loss
change in heart rate variability during and after weight loss
change in measured and predicted resting metabolic rate during and after weight loss

Trial Safety

Trial Design

2 Treatment Groups

lifestyle intervention
1 of 2
lifestyle intervention plus phentermine-topiramate
1 of 2

Experimental Treatment

60 Total Participants · 2 Treatment Groups

Primary Treatment: lifestyle intervention with meal replacement program · No Placebo Group · N/A

lifestyle intervention
Other
Experimental Group · 1 Intervention: lifestyle intervention with meal replacement program · Intervention Types: Other
lifestyle intervention plus phentermine-topiramate
Other
Experimental Group · 1 Intervention: phentermine-topiramate combined with lifestyle intervention · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 18 months

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
566 Previous Clinical Trials
1,154,058 Total Patients Enrolled
3 Trials studying Weight Loss
280 Patients Enrolled for Weight Loss
Lisa L Morselli, MD PhDPrincipal InvestigatorMedical College of Wisconsin

Eligibility Criteria

Age 18 - 50 · All Participants · 1 Total Inclusion Criteria

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Who else is applying?

What state do they live in?
Georgia33.3%
Florida33.3%
Wisconsin33.3%
How old are they?
18 - 65100.0%
What site did they apply to?
Medical College of Wisconsin100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

How responsive is this trial?

Typically responds via
Email100.0%
Most responsive sites:
  1. Medical College of Wisconsin: < 48 hours
Average response time
  • < 2 Days