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Radiation Therapy

Adaptive Radiotherapy for Glioblastoma (UNITED Trial)

N/A

Waitlist Available

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients aged 18 years and older

Histopathologically confirmed malignant glioma of the brain, Grade 4 (GBM)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

UNITED Trial Summary

This trial is testing a new way to give radiation therapy for brain tumors that may result in less side effects.

Who is the study for?

This trial is for adults over 18 with a specific brain tumor called Grade 4 glioblastoma, who can communicate in English and have an expected survival of more than 12 weeks. They should be fit enough for radiotherapy or chemo and have a tumor volume less than 150 cm3. It's not suitable for those unable to wear a head mask, with certain previous treatments, weight over 140 kg, MRI contraindications, or poor kidney function.Check my eligibility

What is being tested?

The study tests adaptive radiotherapy using MR-Linac technology on patients with high-grade gliomas. This method updates the treatment plan daily based on MRI scans to target tumors more precisely and reduce healthy brain tissue exposure compared to standard non-adaptive methods.See study design

What are the potential side effects?

Potential side effects may include typical radiation therapy risks such as skin irritation at the treatment site, fatigue, headaches, nausea, hair loss near treated areas and potential cognitive changes due to reduced exposure of healthy brain tissue.

UNITED Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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My brain tumor is a confirmed Grade 4 glioma.

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I am eligible for radiation therapy, with or without a specific chemotherapy drug.

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I can perform light activities but not work.

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My treatment area is smaller than 150 cm3.

UNITED Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Imaging-detected tumor recurrence at the edge of the radiation volume ("marginal" failure)

Secondary outcome measures

Acute radiation toxicity based on RTOG/EORTC Common Toxicity Criteria

Dexamethasone usage

Quality of life based on EORTC QLQ-BN20

+2 more

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,551,329 Total Patients Enrolled

3 Trials studying Glioblastoma

105 Patients Enrolled for Glioblastoma

Media Library

Radiotherapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04726397 — N/A

Glioblastoma Clinical Trial 2023: Radiotherapy Highlights & Side Effects. Trial Name: NCT04726397 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants can join this experiment?

"Affirmative. The clinicaltrial.gov site conveys that this medical trial, which opened on March 29th 2021, is still actively looking for participants. A total of 97 patients need to be enrolled from one location specifically."

Answered by AI

Are there opportunities for new participants to join this research endeavor?

"According to clinicaltrials.gov, this medical trial is currently recruiting participants. It was first published on March 29th 2021 and the information was most recently updated October 19th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: A Phase 2 Trial

Jay Detsky 2021. "UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: A Phase 2 Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04726397.