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Pre-Chemo Exercise for Ovarian Cancer

N/A
Recruiting
Led By Siddhartha S Angadi, PhD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 years or over
Presumed diagnosis of ovarian cancer and a planned chemotherapy regimen of a taxane and carboplatin with or without VEGF inhibition
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 22 weeks
Awards & highlights

Study Summary

This trial looks at whether working out before chemo can help reduce negative side effects like heart problems, nerve damage, and reduced quality of life.

Who is the study for?
This trial is for adults over 18 with a presumed diagnosis of ovarian cancer who are about to start chemotherapy. They must be cleared by a doctor for exercise and willing to follow the study's rules. People can't join if they've had chemo in the last 5 years, have cancer recurrence, or conditions that make exercising unsafe.Check my eligibility
What is being tested?
The study is testing whether doing high intensity interval exercises before starting chemotherapy can help protect heart health, reduce nerve damage, and improve life quality compared to standard care without special exercise routines.See study design
What are the potential side effects?
While not directly related to side effects of drugs, participants may experience typical exercise-related discomforts such as muscle soreness or fatigue. The intervention aims to lessen rather than cause side effects from chemotherapy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
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I am diagnosed with ovarian cancer and will be treated with specific chemotherapy drugs.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~22 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 22 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
VO2 Peak
Secondary outcome measures
Blood pressure
Brachial Artery Endothelium-Dependent Flow-Mediated Dilation
Carotid-Femoral Pulse Wave Velocity
+7 more
Other outcome measures
Fasting Blood Glucose
Inflammation
Insulin
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ExerciseExperimental Treatment1 Intervention
Patients in the exercise group will perform interval training 3 days per week.
Group II: Attention ControlPlacebo Group1 Intervention
Physical activity education and physical activity monitoring.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High intensity interval exercise
2018
N/A
~100

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor
754 Previous Clinical Trials
1,245,046 Total Patients Enrolled
4 Trials studying Ovarian Cancer
662 Patients Enrolled for Ovarian Cancer
Siddhartha S Angadi, PhDPrincipal InvestigatorUniversity of Virginia
3 Previous Clinical Trials
126 Total Patients Enrolled

Media Library

High intensity interval exercise Clinical Trial Eligibility Overview. Trial Name: NCT05029154 — N/A
Ovarian Cancer Research Study Groups: Exercise, Attention Control
Ovarian Cancer Clinical Trial 2023: High intensity interval exercise Highlights & Side Effects. Trial Name: NCT05029154 — N/A
High intensity interval exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05029154 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Exercise Preconditioning in Ovarian Cancer
Siddartha Angadi 2021. "Exercise Preconditioning in Ovarian Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05029154.
~4 spots leftby Oct 2024
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