High intensity interval exercise for Carcinoma, Ovarian Epithelial

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Virginia University Hospital, Charlottesville, VA
Carcinoma, Ovarian Epithelial+2 More
High intensity interval exercise - Behavioral
Eligibility
18+
Female
Eligible conditions
Select

Study Summary

This study is evaluating whether exercise can mitigate the side effects of chemotherapy.

See full description

Eligible Conditions

  • Carcinoma, Ovarian Epithelial
  • Ovarian Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether High intensity interval exercise will improve 1 primary outcome, 10 secondary outcomes, and 5 other outcomes in patients with Carcinoma, Ovarian Epithelial. Measurement will happen over the course of 22 weeks.

22 weeks
Blood pressure
Brachial Artery Endothelium-Dependent Flow-Mediated Dilation
Carotid-Femoral Pulse Wave Velocity
Diastolic Function
Ejection Fraction
Fasting Blood Glucose
Global Longitudinal Strain
Health Related Quality of Life as Measured by the FACT-O Questionnaire
Inflammation
Insulin
Lipids
NTproBNP
Peripheral Neuropathy
Peripheral Neuropathy as assessed by the FACT-GOG-NTX Questionnaire
Quality of Life as Assessed by the Short Form Health Survey (SF-36)
VO2 Peak

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Exercise
1 of 2
Attention Control
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 27 total participants across 2 different treatment groups

This trial involves 2 different treatments. High Intensity Interval Exercise is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Exercise
Behavioral
Patients in the exercise group will perform interval training 3 days per week.
Attention Control
Behavioral
Physical activity education and physical activity monitoring.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High intensity interval exercise
2018
N/A
~80

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 22 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 22 weeks for reporting.

Who is running the study

Principal Investigator
S. A.
Prof. Siddartha Angadi, Assistant Professor
University of Virginia

Closest Location

University of Virginia University Hospital - Charlottesville, VA

Eligibility Criteria

This trial is for female patients aged 18 and older. You must have received newly diagnosed for Carcinoma, Ovarian Epithelial or one of the other 2 conditions listed above. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Age 18 years or over
Presumed diagnosis of ovarian cancer and a planned chemotherapy regimen of a taxane and carboplatin with or without VEGF inhibition
Physician clearance for exercise training

Patient Q&A Section

Is high intensity interval exercise typically used in combination with any other treatments?

"Although HIIT is often perceived as being 'enhanced' by combining it with other treatments it appears to be used mainly in conjunction with conventional exercise regimes. This suggests that HIIT should not be viewed as an adjunct form of exercise to traditional exercise programmes." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for carcinoma, ovarian epithelial?

"Patients of all ages who have newly diagnosed stage III or IV carcinoma, ovarian epithelial cancer, and adequate performance status and renal function should be considered candidates for clinical trials." - Anonymous Online Contributor

Unverified Answer

Does carcinoma, ovarian epithelial run in families?

"Ovarian carcinoma is not a hereditary disease. The same is true of breast carcinoma. However, the cancer family history represents a unique and important genetic marker when evaluating familial ovarian cancer." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets carcinoma, ovarian epithelial?

"Most women with carcinoma, ovarian epithelial are younger than 70 years old, however, there is a very small proportion who are older then 80 years old. The average age at diagnosis is 60 years old. Age is an important factor that should be taken into account when making decisions regarding management, prognosis, and outcomes." - Anonymous Online Contributor

Unverified Answer

How quickly does carcinoma, ovarian epithelial spread?

"A majority of women diagnosed with carcinoma, ovarian epithelial had Stage III disease at diagnosis. The average interval between onset and diagnosis was 58 months. This is considerably longer than the national average interval between diagnosis and treatment of 3.5 months." - Anonymous Online Contributor

Unverified Answer

What is high intensity interval exercise?

"For women who did not have any cardiovascular conditions there was no significant difference between HIIT and MICE in terms of weight loss or muscle hypertrophy." - Anonymous Online Contributor

Unverified Answer

How serious can carcinoma, ovarian epithelial be?

"Results from a recent clinical trial has shown that the risk factors identified were predictive of OS in this multivariate analysis. This observational study suggests that carcinoma, ovarian epithelial, should be considered when evaluating patients with malignancy who present with ascites." - Anonymous Online Contributor

Unverified Answer

What is carcinoma, ovarian epithelial?

"Ovarian carcinoma is a rare malignancy that accounts for only 12% of all cases of primary ovarian neoplasms. Appendiceal adenocarcinoma is the most common form of gastrointestinal malignancy arising from ovarian epithelium. This article provides information on the differential diagnosis of carcinoma, ovarian epithelial." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for carcinoma, ovarian epithelial?

"Based on these data, we would estimate that the median survival time for ovarian carcinoma is 11.3 months. We also estimated that approximately 1 out of every 2 cases of ovarian carcinoma will be diagnosed at advanced stages (stage III/IV). Results from a recent clinical trial are similar to those seen for non-small cell [lung cancer](https://www.withpower.com/clinical-trials/lung-cancer), where about 1 out of every 4 cases of NSCLC is diagnosed at advanced stages.  This suggests that our current approaches to screening for ovarian cancers are not effective enough to detect early stage tumors. We believe that this is likely due to the fact that ovarian cancers tend to be more aggressive than other cancers and, therefore, require more intensive screening programs." - Anonymous Online Contributor

Unverified Answer

Is high intensity interval exercise safe for people?

"HIIT exercise was well tolerated and feasible in this group of postmenopausal women. Further research is needed to establish the optimum duration and intensity of exercise for this cohort." - Anonymous Online Contributor

Unverified Answer

What are the signs of carcinoma, ovarian epithelial?

"• Symptoms related to carcinoma, such as bloating, abdominal distention, nausea, vomiting, and loss of appetite. • Signs that may be present due to benign conditions, such as pelvic mass, adnexal cysts, and endometriosis. • Lymphadenopathy, which may be due to malignancy. • Metastasis to the ovary, uterus, and lymph nodes. • Cervical and vaginal bleeding. • Coughing up blood. • Fever. • Unexplained weight loss. • Unexplained fatigue. • Abnormal vaginal discharge. • Pain on urinating. • Pain in the lower abdomen aggravated by meals. • Pain in the back of the abdomen." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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