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Fluid responder for Fluid Responsiveness (PHOENIX Trial)
N/A
Recruiting
Led By Ramakanth Pata, MD FCCP
Research Sponsored by CentraCare
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours after the initial passive leg raise
Awards & highlights
PHOENIX Trial Summary
In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.
PHOENIX Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 hours after the initial passive leg raise
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours after the initial passive leg raise
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Vasopressor dose in Nor-epinephrine equivalents (NE) measured as mcg/kg/min
PHOENIX Trial Design
2Treatment groups
Experimental Treatment
Group I: Fluid responderExperimental Treatment1 Intervention
Stability of vasopressor dose with maximum of 500 cc of crystalloids
Group II: Fluid non responderExperimental Treatment0 Interventions
Escalating dose of vasopressors despite 1 L of crystalloid fluid challenge
Find a Location
Who is running the clinical trial?
CentraCareLead Sponsor
4 Previous Clinical Trials
2,338 Total Patients Enrolled
Ramakanth Pata, MD FCCPPrincipal InvestigatorCentracare health System
1 Previous Clinical Trials
50 Total Patients Enrolled
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