Treatment for Adductor Spastic Dysphonia of Dystonia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Indiana University, Indianapolis, IN
Adductor Spastic Dysphonia of Dystonia+4 More
Eligibility
18+
All Sexes
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Study Summary

Deep Brain Stimulation is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional MRI. While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as MRI.

Eligible Conditions

  • Adductor Spastic Dysphonia of Dystonia
  • Laryngeal Dystonia

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 6 Secondary · Reporting Duration: Before surgery, within 24 hours after surgery, 6 months after surgery

Month 6
Change in Neuropsychological testin: Trails B
Change in Neuropsychological testing: Controlled Oral Word Association Animal fluency
Change in Neuropsychological testing: Trails A
Month 6
Change in Acoustic voice recordings
Change in total number of Vocal fold movements
Month 9
Change in Speech Intelligibility
Change in Voice Handicap Index
before surgery and 6-9months after surgery
Change in Resting state fMRI
during surgery
Microelectrode recording

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

12 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: before surgery, within 24 hours after surgery, 6 months after surgery

Trial Background

Prof. S. Elizabeth Zauber, Associate Professor of Clinical Neurology
Principal Investigator
Indiana University
Closest Location: Indiana University · Indianapolis, IN
Photo of Indiana University  1Photo of Indiana University  2Photo of Indiana University  3
1992First Recorded Clinical Trial
1 TrialsResearching Adductor Spastic Dysphonia of Dystonia
411 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have no evidence of severe untreated mood disorder as assessed by a neurologist, or as evident on self-report (Beck Depression Inventory-II score > 29, Beck Anxiety Inventory Score > 26).
You are 18 years or older.
You are native speakers of American English.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.