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Paravertebral Blocks (PVB) for Breast Disease

N/A
Waitlist Available
Led By Pamela Morgan, MD, CCFP, FRCPC
Research Sponsored by Women's College Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

General anesthesia and morphine based pain medicine analgesia has been the mainstay of practice in breast cancer surgery at Women's College Hospital. There is evidence to suggest that patients have a better recovery, with less pain and nausea and vomiting when nerve blocks or freezing of nerves are given in addition to a general anesthetic. Specifically for breast cancer surgery, evidence has suggested that the use of paravertebral blocks provide patients with a better quality of recovery after surgery. The aim of this study is to examine whether patients who receive the nerve blocks using an ultrasound machine in addition to general anesthesia have a better quality of recovery than patients who receive a general anesthetic alone. The hypothesis is that patients receiving ultrasound-guided paravertebral blocks (PVB) with propofol-based general anesthesia (GA) will have a better quality of recovery than patients receiving general anesthesia-opioid-analgesia. Quality of recovery will be assessed using a modification of the QoR-27, a validated instrument to assess postoperative recovery in an ambulatory surgical population.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The measure is the quality of recovery at discharge as assessed by the QoR27
The measure is the quality of recovery post operatively as assessed by the QoR27
The measure is the quality of recovery post operatively, as assessed by the QoR27
Secondary outcome measures
Neuropathic pain

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Paravertebral Blocks (PVB)Active Control1 Intervention
Breast cancer surgery under ultrasound-guided paravertebral blocks plus general anesthesia
Group II: General anaesthesia and sham nerve blockPlacebo Group1 Intervention
Breast cancer surgery under general anaesthesia

Find a Location

Who is running the clinical trial?

Women's College HospitalLead Sponsor
101 Previous Clinical Trials
39,032 Total Patients Enrolled
Ontario Ministry of Health and Long Term CareOTHER_GOV
91 Previous Clinical Trials
107,964 Total Patients Enrolled
Pamela Morgan, MD, CCFP, FRCPCPrincipal InvestigatorWomen's College Hospital

Frequently Asked Questions

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~4 spots leftby Apr 2025