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Non-invasive Brain Stimulation
Active -> Sham for Borderline Personality Disorder (rTMS Trial)
N/A
Waitlist Available
Led By Dr. Jonathan Downar, MD PhD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to first followup (1 week post treatment), 3 months post-treatment
Awards & highlights
rTMS Trial Summary
This randomized trial with a crossover design will examine the efficacy of rTMS targeting the dorsomedial prefrontal cortex as a treatment for medication-resistant major depression in patients meeting diagnostic criteria for borderline personality disorder.
Eligible Conditions
- Borderline Personality Disorder
- Depression
rTMS Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline to first followup (1 week post treatment), 3 months post-treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to first followup (1 week post treatment), 3 months post-treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
HRSD-17 change
Secondary outcome measures
ZAN-BPD change
rTMS Trial Design
2Treatment groups
Experimental Treatment
Group I: Sham -> ActiveExperimental Treatment1 Intervention
15 days of sham, followed by 15 days of active rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold
Group II: Active -> ShamExperimental Treatment1 Intervention
15 days of active, followed by 15 days of sham rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold
Find a Location
Who is running the clinical trial?
University Health Network, TorontoLead Sponsor
1,476 Previous Clinical Trials
485,160 Total Patients Enrolled
Dr. Jonathan Downar, MD PhDPrincipal InvestigatorUniversity Health Network, Toronto
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who else is applying?
What state do they live in?
Alberta
What site did they apply to?
Toronto Western Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
2
3+
Why did patients apply to this trial?
I've been contending with BPD for all my life, and every moment of every day is an exercise in learning how to mediate my emotions and learning to distinguish the disorder from me, which is a pointless exercise to a certain degree. I have been on and off psychotherapy and antidepressants and nothing has really worked so far. Being part of a novel clinical therapeutic trial would not only give me a shot at learning and being able to live with this disorder better but it would do the same for people with BPD the world over.
PatientReceived 1 prior treatment
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