120 Participants Needed

Perceptual Learning Study in Sensory and Motor Function

HB
Overseen ByHannah Block, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Indiana University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning). The investigators hope this information may be useful one day to improve rehabilitation techniques in patients with brain lesions.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is perceptual learning in sensory and motor function safe for humans?

The studies suggest that perceptual learning, which involves training the brain to improve sensory and motor skills, is generally safe for humans. These studies did not report any harmful effects, indicating that this type of training is well-tolerated.12345

How does the Perceptual Learning Study in Sensory and Motor Function treatment differ from other treatments?

This treatment is unique because it combines perceptual learning with motor learning, which means it not only focuses on improving motor skills but also enhances sensory perception. This dual approach leads to changes in both sensory and motor areas of the brain, potentially offering more comprehensive improvements in sensorimotor function compared to treatments that target only motor or sensory systems separately.12678

What data supports the effectiveness of this treatment in the Perceptual Learning Study in Sensory and Motor Function?

Research shows that sensory and motor learning can improve tactile and proprioceptive (sense of body position) abilities in stroke patients, suggesting that similar training might enhance sensory and motor functions in other contexts. Additionally, placebo effects, which are improvements due to belief in treatment rather than the treatment itself, can be conditioned and may contribute to perceived effectiveness.910111213

Who Is on the Research Team?

HB

Hannah Block

Principal Investigator

Indiana University, Bloomington

Are You a Good Fit for This Trial?

This trial is for right-handed individuals aged 18-45, free of COVID symptoms and fully vaccinated or with a recent negative test. Exclusions include BMI over 30, inability to perform tasks or follow instructions, IUD users without MR compatibility confirmation, claustrophobia, pregnancy, vision issues not correctable by MRI-compatible glasses at the center, neurological disorders or upper limb conditions.

Inclusion Criteria

Right-handed
I have not had COVID-19 symptoms in the last week.

Exclusion Criteria

Pregnant women or those who suspect they might be pregnant
I can follow instructions and perform tasks during the study.
Use of an intra-uterine device (IUD) whose MR compatibility has not been established
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day
1 visit (in-person)

Familiarization

Participants undergo a familiarization session for fMRI and the behavioral task

30-40 minutes
1 visit (in-person)

Main Session

Participants perform the main session tasks including resting state scans and behavioral tasks

2 hours
1 visit (in-person)

Follow-up

Participants are monitored for any immediate effects post-session

1 day

What Are the Treatments Tested in This Trial?

Interventions

  • Control
  • Motor learning
  • Perceptual learning
Trial Overview The study aims to explore how sensory and motor brain areas collaborate during hand movement learning. Participants will engage in perceptual learning while their brain function is monitored. The goal is to gather insights that could enhance rehabilitation methods for patients with brain damage.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Perceptual learningExperimental Treatment1 Intervention
Group II: ControlActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials
1,063
Recruited
1,182,000+

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Trials
1,403
Recruited
655,000+

Published Research Related to This Trial

In a study involving 13 healthy young adults, repeated administrations of the Sensory Organization Test (SOT) showed a significant learning effect, with performance improving notably after three sessions and maintaining those gains after one month.
A change of more than 8 points in the composite score of the SOT indicates a clinically meaningful improvement, suggesting that multiple baseline measures are beneficial for assessing rehabilitation progress.
Learning effects of repetitive administrations of the sensory organization test in healthy young adults.Wrisley, DM., Stephens, MJ., Mosley, S., et al.[2022]
The study involving 30 healthy volunteers found that performing the sensory organization test multiple times led to significant improvements in equilibrium scores, indicating a practice effect.
Clinicians and researchers should consider allowing one practice trial before recording baseline measurements, as initial tests showed notable increases in scores, particularly under specific conditions like vision removal.
Assessment of a practice effect in serial sensory organization testing scores of healthy adults.Grindstaff, TL., Christiano, KE., Broos, AM., et al.[2019]
Placebo effects can lead to real health improvements and are influenced by brain regions and neurotransmitter systems, such as opiate and dopamine pathways, highlighting their importance in clinical trials.
A patient's expectation of improvement can significantly impact treatment outcomes, sometimes rivaling the effects of active interventions, suggesting that enhancing this expectancy could be crucial for effective patient care.
Placebo effects: clinical aspects and neurobiology.Oken, BS.[2022]

Citations

Learning effects of repetitive administrations of the sensory organization test in healthy young adults. [2022]
Assessment of a practice effect in serial sensory organization testing scores of healthy adults. [2019]
Placebo effects: clinical aspects and neurobiology. [2022]
Sensory loss in stroke patients: effective training of tactile and proprioceptive discrimination. [2022]
Conditioned placebo responses. [2019]
Somatosensory plasticity and motor learning. [2022]
Perceptual learning in sensorimotor adaptation. [2022]
Influence of Visual Feedback on Roll Tilt Perceptual Training. [2023]
Audio Feedback Associated With Body Movement Enhances Audio and Somatosensory Spatial Representation. [2023]
10.United Statespubmed.ncbi.nlm.nih.gov
Somatosensory Contribution to the Initial Stages of Human Motor Learning. [2022]
11.United Statespubmed.ncbi.nlm.nih.gov
Structure of plasticity in human sensory and motor networks due to perceptual learning. [2022]
12.United Statespubmed.ncbi.nlm.nih.gov
Functionally specific changes in resting-state sensorimotor networks after motor learning. [2022]
Sensory Plasticity in Human Motor Learning. [2018]
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