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Virtual Dental Office Experience for Autism Spectrum Disorder

Waitlist Available
Led By Azadeh Kushki, PhD
Research Sponsored by Holland Bloorview Kids Rehabilitation Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
A community diagnosis of ASD
Aged 4-12
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights


This trialwill test if virtual reality (360° video) is better than a social story to reduce dental anxiety in children with ASD, and if it is cost effective.

Who is the study for?
This trial is for children aged 4-12 with autism spectrum disorder who have a dental appointment at least 3 weeks away and are predicted to have difficulty sitting through it. It's their first time at Holland Bloorview Dental, and they must have an ASD diagnosis from the community.Check my eligibility
What is being tested?
The study compares two methods to reduce pre-visit anxiety for dental appointments in children with ASD: one uses virtual reality (360° video) while the other uses a social story. The cost of both methods will also be compared.See study design
What are the potential side effects?
Since this trial involves non-invasive interventions like watching videos or reading stories, there are no significant medical side effects expected. However, individual reactions to VR experiences can vary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have been diagnosed with Autism Spectrum Disorder.
I am between the ages of 4 and 12.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dental visit "completeness"
Secondary outcome measures
Pre-visit anxiety
Other outcome measures
Cost comparison analysis
Heart rate

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Experimental Condition (360° Video)Experimental Treatment1 Intervention
The 360° video (experimental) group will be mailed a study tablet with the 360° video prior to the dental visit.
Group II: Control Condition (Social Story)Active Control1 Intervention
The treatment-as-usual (control) group will be mailed a study tablet with a social story prior to the dental visit.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Autism Spectrum Disorder (ASD) often focus on behavioral, educational, and therapeutic interventions designed to improve social skills, communication, and adaptive behaviors. Virtual Reality (360° Video) is an emerging treatment that provides an immersive and engaging experience, which can help distract and calm children with ASD. This matters for Autism patients because it can reduce pre-visit anxiety, making medical or dental visits less stressful and more manageable. The immersive nature of VR can also help children with ASD practice social scenarios in a controlled, safe environment, potentially improving their real-world interactions.
Using virtual reality to target positive autobiographical memory in individuals with moderate-to-moderately severe depressive symptoms: A single case experimental design.Adherence to home-based videogame treatment for amblyopia in children and adults.Virtual reality in psychiatric disorders: A systematic review of reviews.

Find a Location

Who is running the clinical trial?

Holland Bloorview Kids Rehabilitation HospitalLead Sponsor
67 Previous Clinical Trials
13,923 Total Patients Enrolled
Azadeh Kushki, PhDPrincipal InvestigatorHolland Bloorview Kids Rehabilitation Hospital
1 Previous Clinical Trials
41 Total Patients Enrolled

Media Library

Virtual Dental Office Experience Clinical Trial Eligibility Overview. Trial Name: NCT05196230 — N/A
Autism Research Study Groups: Control Condition (Social Story), Experimental Condition (360° Video)
Autism Clinical Trial 2023: Virtual Dental Office Experience Highlights & Side Effects. Trial Name: NCT05196230 — N/A
Virtual Dental Office Experience 2023 Treatment Timeline for Medical Study. Trial Name: NCT05196230 — N/A
~36 spots leftby Jul 2025