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Healthy Participants for Anxiety Disorders

N/A
Waitlist Available
Led By Christian Grillon, Ph.D.
Research Sponsored by National Institute of Mental Health (NIMH)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of study visit
Awards & highlights

Study Summary

This trial will study how different people respond to unpleasant learning experiences, with the goal of understanding how anxiety disorders develop.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~11.2 minutes per run for a total of 22.4 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 11.2 minutes per run for a total of 22.4 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST)
Change in Percent of Correct no Button Presses During Threat Compared to the Safe Condition
Correct-go Reaction Time (RT) - Safe Condition
+21 more
Secondary outcome measures
Skin conductance
state and trait questionaires

Trial Design

2Treatment groups
Experimental Treatment
Group I: Healthy ParticipantsExperimental Treatment1 Intervention
Substudy 1/ Neutral, Predictable, and Unpredictable Responses (NPU): physiological responses to different threat of shock conditions - no shock, unpredictable shock, and predictable-cued shock. Substudy 2/ Working Memory Task: Subjects performed a working memory task under threat of shock and in safety. Substudy 5 /Face Stroop Task: Stimuli were pictures of faces exhibiting anger, disgust, fear, happiness, sadness, and surprise intermixed with pleasant, unpleasant, and neutral pictures. Substudy 7/ Active Avoidance Signal Task (AAST) and Sustained Attention Response Task (SART): In AAST, participants performed paradigms which tested whether threats impact the initiation and the inhibition of behavioral responses. In SART, participants were presented with stimuli and either initiated a go or nogo response. Pilot Tasks: Participants completed one/more tasks: nerve stimulation, short speech, air burst, saliva samples, squeezer task, virtual reality task, or computer-based task.
Group II: Anxiety subjectsExperimental Treatment1 Intervention
Substudy 1/ Neutral, Predictable, and Unpredictable Responses (NPU): physiological responses to different threat of shock conditions - no shock, unpredictable shock, and predictable-cued shock. Substudy 2/ Working Memory Task: Subjects performed a working memory task under threat of shock and in safety. Substudy 5 /Face Stroop Task: Stimuli were pictures of faces exhibiting anger, disgust, fear, happiness, sadness, and surprise intermixed with pleasant, unpleasant, and neutral pictures. Substudy 7/ Active Avoidance Signal Task (AAST) and Sustained Attention Response Task (SART): In AAST, participants performed paradigms which tested whether threats impact the initiation and the inhibition of behavioral responses. In SART, participants were presented with stimuli and either initiated a go or nogo response. Pilot Tasks: Participants completed one/more tasks: nerve stimulation, short speech, air burst, saliva samples, squeezer task, virtual reality task, or computer-based task.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Threat of shock
2003
N/A
~930

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)Lead Sponsor
2,786 Previous Clinical Trials
2,688,778 Total Patients Enrolled
157 Trials studying Anxiety Disorders
64,467 Patients Enrolled for Anxiety Disorders
Christian Grillon, Ph.D.Principal InvestigatorNational Institute of Mental Health (NIMH)
6 Previous Clinical Trials
2,918 Total Patients Enrolled
2 Trials studying Anxiety Disorders
1,119 Patients Enrolled for Anxiety Disorders
Monique Ernst, M.D.Principal InvestigatorNational Institute of Mental Health (NIMH)
10 Previous Clinical Trials
8,467 Total Patients Enrolled
5 Trials studying Anxiety Disorders
4,317 Patients Enrolled for Anxiety Disorders

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Expectation of Unpleasant Events in Anxiety Disorders
2003. "Expectation of Unpleasant Events in Anxiety Disorders". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00055224.
~42 spots leftby Apr 2025
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