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Radiation

Adaptive Radiotherapy for Brain Tumor

N/A

Recruiting

Led By Tony J. Wang, MD

Research Sponsored by Columbia University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Plan to receive 60 Gy in 30 fractions of radiotherapy and not hypofractionated radiotherapy and not hypofractionated radiotherapy including 40 Gy in 15 fractions

Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial investigates if MRI scans during radiation can improve treatment of high-grade brain tumors.

Who is the study for?

This trial is for adults over 18 with high-grade gliomas like glioblastoma, who haven't had previous tumor treatments except biopsy or resection. They must have a Karnofsky performance status of 70+ and plan to receive standard radiotherapy. Pregnant women can't participate.Check my eligibility

What is being tested?

The study tests if extra MRI scans during the weekly radiation treatment can improve outcomes for patients with aggressive brain tumors. It aims to adapt radiotherapy more precisely to the changes in the tumor's size and shape.See study design

What are the potential side effects?

While not explicitly listed, side effects may include typical reactions from regular MRIs and radiotherapy such as headaches, nausea, fatigue, skin irritation at the treatment site, and potential short-term memory issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am scheduled for a specific radiotherapy plan, not a shortened course.

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My diagnosis is a type of aggressive brain tumor.

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I am able to care for myself but cannot do normal activities without help.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Prediction of progression of disease in patients with high-grade glioma.

Secondary outcome measures

Estimate the progression-free and overall survival in patient with high-grade glioma.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Adaptive RadiotherapyExperimental Treatment1 Intervention

Subjects will receive radiotherapy per standard of care over 30 once-daily fractions in addition to 6 brain MRIs each in every week of treatment.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Columbia UniversityLead Sponsor

1,433 Previous Clinical Trials

2,447,239 Total Patients Enrolled

1 Trials studying Oligodendroglioma

15 Patients Enrolled for Oligodendroglioma

Varian Medical SystemsIndustry Sponsor

59 Previous Clinical Trials

3,759 Total Patients Enrolled

Tony J. Wang, MDPrincipal InvestigatorColumbia University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the estimated participation rate among potential candidates for this clinical trial?

"Affirmative. Clinicaltrials.gov reveals that this research trial is actively recruiting volunteers, with first postings on November 1st 2023 and most recent updates occurring October 27th 2023. The project requires the recruitment of twenty participants from one site."

Answered by AI

Is the patient recruitment phase of this trial still underway?

"Affirmative, clinicaltrials.gov highlights that this investigation is presently attempting to recruit participants. It was first listed on November 1st 2023 and the most recent update occurred on October 27th 2023. The team are aiming for a total of twenty recruits from one site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Tony Jau Cheng Wang 2024. "Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06108206.

All > Glioblastoma New York > Oligodendroglioma