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Mucolytic Agent

Acetylcysteine for Creatinine Clearance

N/A

Waitlist Available

Led By Thomas R McCune, MD

Research Sponsored by Eastern Virginia Medical School

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18 and 79 years

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is investigating whether the drug Acetylcysteine has a protective effect on renal function by looking at creatinine clearance. Previous studies have shown that Acetylcysteine can lower the incidence of an increase in serum creatinine after administration of radiographic contrast agents. This trial is looking to see if the increase in creatinine clearance is from a protective benefit of Acetylcysteine in preserving the GFR or if it is simply from an increase in proximal tubular creatinine secretion.

Who is the study for?

This trial is for healthy adults aged 18-79 who can consent to participate. It's not for women of childbearing age not using contraception, people allergic to acetylcysteine or cimetidine, those outside the age range, or anyone on medication affecting creatinine secretion like Bactrim.Check my eligibility

What is being tested?

The study examines how Acetylcysteine (Mucomyst) affects creatinine clearance in the kidneys. It aims to determine if it increases kidney filtration rate or just causes more creatinine to be secreted without improving kidney function.See study design

What are the potential side effects?

While specific side effects are not listed here, Acetylcysteine may typically cause nausea, vomiting, rash and rarely more serious reactions like bronchospasm or anaphylaxis especially in patients with asthma.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 79 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Eastern Virginia Medical SchoolLead Sponsor

69 Previous Clinical Trials

14,416 Total Patients Enrolled

Thomas R McCune, MDPrincipal InvestigatorEastern Virginia Medical School

Media Library

Acetylcysteine (Mucolytic Agent) Clinical Trial Eligibility Overview. Trial Name: NCT00396396 — N/A

Creatinine Clearance Research Study Groups:

Creatinine Clearance Clinical Trial 2023: Acetylcysteine Highlights & Side Effects. Trial Name: NCT00396396 — N/A

Acetylcysteine (Mucolytic Agent) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00396396 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research protocol include participants in the older age range?

"Participants that are 18 years and older, but not yet 79 will be considered for this study."

Answered by AI

What criteria must be met for someone to qualify as a participant in this trial?

"To be eligible for this research, patients must demonstrate creatinine clearance and fall between 18-79 years old. A total of 35 participants will be admitted in the trial."

Answered by AI

What are the applications procedures for this research study?

"This clinical trial, initially listed on October 1st 2006 and last updated November 3rd 2006 is not currently accepting patients. Nevertheless, there are other studies that have openings for participants at this time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Role of Acetylcysteine in Creatinine Clearance

2006. "Role of Acetylcysteine in Creatinine Clearance". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00396396.

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